Details of the Drug Combinations

General Information of This Drug (ID: DM9C8NX)

Drug Name

Trichostatin A DM9C8NX

Synonyms

trichostatin A; 58880-19-6; Trichostatin A (TSA); TSA; Trichostatin; Tricostatin A; UNII-3X2S926L3Z; CHEBI:46024; (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; GNF-PF-1011; RTKIYFITIVXBLE-QEQCGCAPSA-N; 3X2S926L3Z; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-; 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

14 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Trichostatin A + Clindamycin	DC2Y639	Clindamycin	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Panobinostat	DCKM0HS	Panobinostat	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Midostaurin	DCGZBDC	Midostaurin	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Chloroquine	DC2R3D1	Chloroquine	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Quinine	DCT3KT3	Quinine	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Piperaquine	DC28Y6K	Piperaquine	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Pyronaridine	DCIQP1G	Pyronaridine	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Mefloquine	DCYUDT5	Mefloquine	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Nitisinone	DC4QHDN	Nitisinone	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Atovaquone	DC5WWO2	Atovaquone	DD2 (Cell Line: DD2)	[2]
Trichostatin A + Clindamycin	DC8OTQR	Clindamycin	Hepatoblastoma (Cell Line: HB3)	[3]
Trichostatin A + Ruxolitinib	DCUO4RH	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Trichostatin A + Chloroquine	DCLPZYJ	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[3]
Trichostatin A + Quinine	DCZ6KG6	Quinine	Hepatoblastoma (Cell Line: HB3)	[3]
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⏷ Show the Full List of 14 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7005).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.