Details of the Drug Combinations

General Information of This Drug (ID: DMA14PR)

Drug Name

TPCA-1 DMA14PR

Synonyms

TPCA1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
TPCA-1 + Ruxolitinib	DCH0PS3	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
TPCA-1 + Idarubicin	DCJVTTH	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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References

1	Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbo... J Pharmacol Exp Ther. 2005 Jan;312(1):373-81.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.