Details of the Drug Combinations

General Information of This Drug (ID: DMA9MP5)

Drug Name

BN-2629 DMA9MP5

Synonyms

SG-2000; SJG-136; SP-2001

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ABT-263 + BN-2629	DCNTBX3	ABT-263	Ewing sarcoma (Cell Line: TC-71)	[2]
BN-2629 + Panobinostat	DCG8P6I	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
BN-2629 + AZD8055	DCQ5ZV7	AZD8055	Ewing sarcoma (Cell Line: TC-71)	[3]
BN-2629 + AT7519	DC1PRON	AT7519	Ewing sarcoma (Cell Line: TC-71)	[3]
BN-2629 + Bardoxolone methyl	DCGJ498	Bardoxolone methyl	Ewing sarcoma (Cell Line: TC-71)	[3]
BN-2629 + Bardoxolone methyl	DC6A841	Bardoxolone methyl	Hodgkin lymphoma (Cell Line: U-HO1)	[2]
Daporinad + BN-2629	DCYT9Y8	Daporinad	Ewing sarcoma (Cell Line: TC-71)	[3]
GDC-0084 + BN-2629	DCOEY77	GDC-0084	Ewing sarcoma (Cell Line: TC-71)	[3]
Lenvatinib + BN-2629	DCDUNDR	Lenvatinib	Ewing sarcoma (Cell Line: TC-71)	[3]
OSI-906 + BN-2629	DCSOZB5	OSI-906	Ewing sarcoma (Cell Line: TC-71)	[2]
SNX-5422 + BN-2629	DC4OK7H	SNX-5422	Ewing sarcoma (Cell Line: TC-71)	[3]
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⏷ Show the Full List of 11 DrugCom(s)

References

1	ClinicalTrials.gov (NCT02034227) Safety, Tolerability Study of SG2000 in the Treatment of Advanced Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia. U.S. National Institutes of Health.
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.