Details of the Drug Combinations

General Information of This Drug (ID: DMAD2OZ)

Drug Name

Palovarotene DMAD2OZ

Synonyms

R-667; RG-667; Retinoid receptor agonist, Roche; Ro-3300074; Ro-330074

Indication

Disease Entry	ICD 11	Status	REF
Fibrodysplasia ossificans progressiva	FB31.1	Approved	[1]
Emphysema	CA21	Phase 2	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Palovarotene + Midazolam	DCEP1AF	Midazolam	Fibrodysplasia Ossificans Progressiva	[3]
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References

1	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 215559
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8276).
3	ClinicalTrials.gov (NCT04829773) Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects