Details of the Drug Combinations

General Information of This Drug (ID: DMAE6LK)

Drug Name

Topetecan DMAE6LK

Synonyms

TOPOTECAN HYDROCHLORIDE; 119413-54-6; Topotecan Hcl; Hycamptamine hydrochloride; Topotecan (Hydrochloride); Topotecan monohydrochloride; UNII-956S425ZCY; Topotecan hydrochloride [USAN]; Nogitecan hydrochloride; DRG-0288; F S-104864-A; NSC-609699; NSC 609699; NSC609699; 956S425ZCY; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione monohydrochloride; NCGC00095189-01; AK-48920; DSSTox_RID_81248; DSSTox_CID_25952

Indication

Disease Entry	ICD 11	Status	REF
Small-cell lung cancer	2C25.Y	Approved	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

266 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
10-hydroxycamptothecin + Topetecan	DCDSFJ0	10-hydroxycamptothecin	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
10-hydroxycamptothecin + Topetecan	DCOY783	10-hydroxycamptothecin	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
10-hydroxycamptothecin + Topetecan	DCXW2S0	10-hydroxycamptothecin	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
10-hydroxycamptothecin + Topetecan	DCRP3VF	10-hydroxycamptothecin	Clear cell renal cell carcinoma (Cell Line: 786-0)	[2]
10-hydroxycamptothecin + Topetecan	DCU4BT1	10-hydroxycamptothecin	Glioma (Cell Line: SF-539)	[2]
10-hydroxycamptothecin + Topetecan	DCW0QG2	10-hydroxycamptothecin	Papillary renal cell carcinoma (Cell Line: ACHN)	[2]
10-hydroxycamptothecin + Topetecan	DC6GYJT	10-hydroxycamptothecin	Renal cell carcinoma (Cell Line: SN12C)	[2]
10-hydroxycamptothecin + Topetecan	DCC8BXS	10-hydroxycamptothecin	Breast adenocarcinoma (Cell Line: MDA-MB-468)	[3]
10-hydroxycamptothecin + Topetecan	DCLAW1L	10-hydroxycamptothecin	Adenocarcinoma (Cell Line: DU-145)	[4]
10-hydroxycamptothecin + Topetecan	DCQFK31	10-hydroxycamptothecin	Adenocarcinoma (Cell Line: A549)	[4]
10-hydroxycamptothecin + Topetecan	DCAQZW2	10-hydroxycamptothecin	Adenocarcinoma (Cell Line: HCT116)	[4]
10-hydroxycamptothecin + Topetecan	DC7E9BG	10-hydroxycamptothecin	Large cell lung carcinoma (Cell Line: NCI-H460)	[4]
10-hydroxycamptothecin + Topetecan	DCNMWLQ	10-hydroxycamptothecin	Lung adenocarcinoma (Cell Line: HOP-62)	[4]
ABIRATERONE + Topetecan	DCQEMCP	ABIRATERONE	Lung adenocarcinoma (Cell Line: MDA-MB-231)	[4]
ABIRATERONE + Topetecan	DC3IP0D	ABIRATERONE	Malignant melanoma (Cell Line: LOX IMVI)	[4]
ABT-263 + Topetecan	DCLBVAK	ABT-263	Glioblastoma (Cell Line: JHH-136)	[4]
Aminolevulinic Acid Hydrochloride + Topetecan	DCUBEF9	Aminolevulinic Acid Hydrochloride	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Aminolevulinic Acid Hydrochloride + Topetecan	DCH94U6	Aminolevulinic Acid Hydrochloride	Adenocarcinoma (Cell Line: HCC-2998)	[4]
Amonafide + Topetecan	DCPT0DJ	Amonafide	Adenocarcinoma (Cell Line: HT29)	[2]
Amonafide + Topetecan	DCNIF9N	Amonafide	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Amonafide + Topetecan	DC1T41T	Amonafide	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Amonafide + Topetecan	DCWIIPI	Amonafide	Astrocytoma (Cell Line: U251)	[2]
Amonafide + Topetecan	DCKBJP1	Amonafide	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Amonafide + Topetecan	DCSYJZA	Amonafide	Lung adenocarcinoma (Cell Line: EKVX)	[2]
Anastrozole + Topetecan	DC1OHOC	Anastrozole	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Anastrozole + Topetecan	DC62BEA	Anastrozole	Astrocytoma (Cell Line: U251)	[2]
Anastrozole + Topetecan	DCSER5R	Anastrozole	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[2]
Anastrozole + Topetecan	DCGPV2K	Anastrozole	Colon adenocarcinoma (Cell Line: COLO 205)	[3]
Arfolitixorin + Topetecan	DCCPRC4	Arfolitixorin	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Arfolitixorin + Topetecan	DC5N9CK	Arfolitixorin	Papillary renal cell carcinoma (Cell Line: ACHN)	[2]
Azacitidine + Topetecan	DCXC8IA	Azacitidine	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Bendamustine hydrochloride + Topetecan	DCKQPS6	Bendamustine hydrochloride	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Bendamustine hydrochloride + Topetecan	DCAB9CV	Bendamustine hydrochloride	Cutaneous melanoma (Cell Line: SK-MEL-5)	[4]
BIO-300 + Topetecan	DCYNT8X	BIO-300	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
BIO-300 + Topetecan	DCPYOCR	BIO-300	Astrocytoma (Cell Line: U251)	[2]
BIO-300 + Topetecan	DCJSQAO	BIO-300	Glioma (Cell Line: SF-295)	[2]
BIO-300 + Topetecan	DCSUQJG	BIO-300	High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES)	[4]
BIO-300 + Topetecan	DCWUKGQ	BIO-300	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
BIO-300 + Topetecan	DCQP1PZ	BIO-300	Pleural epithelioid mesothelioma (Cell Line: NCI-H226)	[4]
Bleomycin + Topetecan	DCKB9OV	Bleomycin	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Bleomycin + Topetecan	DCEBYTT	Bleomycin	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Bleomycin + Topetecan	DC5J6R2	Bleomycin	Glioma (Cell Line: SF-295)	[2]
Bleomycin + Topetecan	DCAYJG6	Bleomycin	Glioma (Cell Line: SF-539)	[2]
Bleomycin + Topetecan	DCKA4P6	Bleomycin	Plasma cell myeloma (Cell Line: RPMI-8226)	[2]
Bleomycin + Topetecan	DCB2H67	Bleomycin	Colon adenocarcinoma (Cell Line: COLO 205)	[3]
Bleomycin + Topetecan	DCSYOMZ	Bleomycin	Colon carcinoma (Cell Line: KM12)	[3]
Bleomycin + Topetecan	DCERCPN	Bleomycin	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Bleomycin + Topetecan	DC4119G	Bleomycin	Adenocarcinoma (Cell Line: SW-620)	[4]
Bleomycin + Topetecan	DCO3LX6	Bleomycin	Adenocarcinoma (Cell Line: HT29)	[4]
Bleomycin + Topetecan	DC2TDWU	Bleomycin	High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES)	[4]
Bleomycin + Topetecan	DCHXMR4	Bleomycin	Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)	[4]
Busulfan + Topetecan	DC1GFS5	Busulfan	Adenocarcinoma (Cell Line: HCT116)	[2]
Busulfan + Topetecan	DCALDAT	Busulfan	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Cabazitaxel + Topetecan	DCYKXXX	Cabazitaxel	Adenocarcinoma (Cell Line: DU-145)	[2]
Cabazitaxel + Topetecan	DCF4972	Cabazitaxel	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Cabazitaxel + Topetecan	DCTY7V8	Cabazitaxel	Clear cell renal cell carcinoma (Cell Line: 786-0)	[2]
Cabazitaxel + Topetecan	DCJMA1J	Cabazitaxel	Glioma (Cell Line: SF-295)	[2]
Cabazitaxel + Topetecan	DCLAEHA	Cabazitaxel	Large cell lung carcinoma (Cell Line: NCI-H460)	[2]
Cabazitaxel + Topetecan	DCL6TTJ	Cabazitaxel	Malignant melanoma (Cell Line: LOX IMVI)	[2]
Cabazitaxel + Topetecan	DCO7LU5	Cabazitaxel	Renal cell carcinoma (Cell Line: SN12C)	[2]
Cabazitaxel + Topetecan	DC6F6LJ	Cabazitaxel	Carcinoma (Cell Line: RXF 393)	[3]
Cabazitaxel + Topetecan	DCFF6C7	Cabazitaxel	Carcinoma (Cell Line: MCF7)	[3]
Crizotinib + Topetecan	DC6W1L9	Crizotinib	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Dacarbazine + Topetecan	DCBEQPY	Dacarbazine	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Dacarbazine + Topetecan	DCKS9IC	Dacarbazine	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Dacarbazine + Topetecan	DCMTM2L	Dacarbazine	Astrocytoma (Cell Line: U251)	[2]
Dacarbazine + Topetecan	DCVPRRZ	Dacarbazine	Glioma (Cell Line: SF-295)	[2]
Dacarbazine + Topetecan	DCPH0NC	Dacarbazine	Pleural epithelioid mesothelioma (Cell Line: NCI-H226)	[2]
Dactinomycin + Topetecan	DCDGMM8	Dactinomycin	Adenocarcinoma (Cell Line: OVCAR3)	[4]
Dactinomycin + Topetecan	DC1EM5L	Dactinomycin	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[4]
Dactinomycin + Topetecan	DCQXAYK	Dactinomycin	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[4]
Dactinomycin + Topetecan	DCI5I36	Dactinomycin	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[4]
Dactinomycin + Topetecan	DCBBPAS	Dactinomycin	High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)	[4]
Dasatinib + Topetecan	DCE109I	Dasatinib	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Dexrazoxane + Topetecan	DCNU4DP	Dexrazoxane	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Docetaxel + Topetecan	DC8O82W	Docetaxel	Adenocarcinoma (Cell Line: NCIH23)	[2]
Epirubicin + Topetecan	DC2CKQQ	Epirubicin	Invasive ductal carcinoma (Cell Line: HS 578T)	[3]
Estramustine + Topetecan	DCKAG1C	Estramustine	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Estramustine + Topetecan	DCDYNQG	Estramustine	Breast adenocarcinoma (Cell Line: MDA-MB-468)	[3]
Estramustine + Topetecan	DCVJ74G	Estramustine	Melanoma (Cell Line: SK-MEL-2)	[4]
Estramustine + Topetecan	DC475B7	Estramustine	Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)	[4]
Fludarabine + Topetecan	DCNVWCF	Fludarabine	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Fludarabine + Topetecan	DCP6BSI	Fludarabine	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Fludarabine + Topetecan	DCX3B3A	Fludarabine	Adenocarcinoma (Cell Line: DU-145)	[4]
Fludarabine + Topetecan	DCL9PVC	Fludarabine	Adenocarcinoma (Cell Line: HCT116)	[4]
Fludarabine + Topetecan	DCZJGBL	Fludarabine	Large cell lung carcinoma (Cell Line: NCI-H460)	[4]
FORMESTANE + Topetecan	DCYZA98	FORMESTANE	Adenocarcinoma (Cell Line: HCT116)	[2]
FORMESTANE + Topetecan	DCWVJ5A	FORMESTANE	Colon adenocarcinoma (Cell Line: COLO 205)	[3]
Gefitinib + Topetecan	DCWKMMC	Gefitinib	Adenocarcinoma (Cell Line: NCIH23)	[2]
Gefitinib + Topetecan	DCK99LA	Gefitinib	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Gefitinib + Topetecan	DCXSUJF	Gefitinib	High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)	[2]
Gefitinib + Topetecan	DCZH09I	Gefitinib	High grade ovarian serous adenocarcinoma (Cell Line: NCI\\/ADR-RES)	[2]
Gefitinib + Topetecan	DCIDNER	Gefitinib	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[2]
Gefitinib + Topetecan	DCA1SJL	Gefitinib	Papillary renal cell carcinoma (Cell Line: ACHN)	[2]
Gefitinib + Topetecan	DCGF2O8	Gefitinib	Pleural epithelioid mesothelioma (Cell Line: NCI-H226)	[2]
Hepzato + Topetecan	DCFDCI3	Hepzato	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Idarubicin + Topetecan	DCKCG63	Idarubicin	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Imatinib + Topetecan	DCMANX9	Imatinib	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Indazole derivative 5 + Topetecan	DCEP3YJ	Indazole derivative 5	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
JNK-IN-8 + Topetecan	DC2SNYV	JNK-IN-8	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
JNK-IN-8 + Topetecan	DCVB2WY	JNK-IN-8	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
JNK-IN-8 + Topetecan	DCJ3B5G	JNK-IN-8	Papillary renal cell carcinoma (Cell Line: ACHN)	[2]
Lenalidomide + Topetecan	DC5JJ5R	Lenalidomide	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
Letrozole + Topetecan	DCYTHE6	Letrozole	Non-small cell lung carcinoma (Cell Line: HOP-92)	[2]
LIAROZOLE + Topetecan	DCFV1IF	LIAROZOLE	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
LIAROZOLE + Topetecan	DCCK7E2	LIAROZOLE	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
LIAROZOLE + Topetecan	DCFXXND	LIAROZOLE	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
LIAROZOLE + Topetecan	DCPKCA5	LIAROZOLE	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
LIAROZOLE + Topetecan	DCUQNUV	LIAROZOLE	Adenocarcinoma (Cell Line: DU-145)	[4]
LIAROZOLE + Topetecan	DCK4WF7	LIAROZOLE	Adenocarcinoma (Cell Line: HCT116)	[4]
LIAROZOLE + Topetecan	DC1MVPR	LIAROZOLE	High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-8)	[4]
LIAROZOLE + Topetecan	DC2FOG9	LIAROZOLE	Large cell lung carcinoma (Cell Line: NCI-H460)	[4]
Mechlorethamine + Topetecan	DCHTC06	Mechlorethamine	Lung adenocarcinoma (Cell Line: EKVX)	[4]
Mepacrine + Topetecan	DCW22PY	Mepacrine	Adenocarcinoma (Cell Line: HCC-2998)	[4]
Mercaptopurine + Topetecan	DC1438Y	Mercaptopurine	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Mercaptopurine + Topetecan	DCXJ3R5	Mercaptopurine	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Mercaptopurine + Topetecan	DC2DKE7	Mercaptopurine	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Mercaptopurine + Topetecan	DCVDB7M	Mercaptopurine	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Mercaptopurine + Topetecan	DCGWRGX	Mercaptopurine	Glioma (Cell Line: SF-539)	[2]
Mercaptopurine + Topetecan	DCGI2B8	Mercaptopurine	Plasma cell myeloma (Cell Line: RPMI-8226)	[2]
Mercaptopurine + Topetecan	DCB13CI	Mercaptopurine	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Mercaptopurine + Topetecan	DCRW7VZ	Mercaptopurine	Adenocarcinoma (Cell Line: NCIH23)	[4]
Mercaptopurine + Topetecan	DCGMD2D	Mercaptopurine	Adenocarcinoma (Cell Line: HCT116)	[4]
Picoplatin + Topetecan	DCDHM2T	Picoplatin	Glioma (Cell Line: SF-295)	[2]
Picoplatin + Topetecan	DCZ132G	Picoplatin	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
Plicamycin + Topetecan	DCRA9VD	Plicamycin	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Plicamycin + Topetecan	DCSFW72	Plicamycin	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Plicamycin + Topetecan	DC203AP	Plicamycin	Colon adenocarcinoma (Cell Line: COLO 205)	[3]
Plicamycin + Topetecan	DCXS0RS	Plicamycin	Adenocarcinoma (Cell Line: OVCAR3)	[4]
Plicamycin + Topetecan	DCAAIY5	Plicamycin	Adenocarcinoma (Cell Line: HT29)	[4]
Plicamycin + Topetecan	DCQKMMP	Plicamycin	Adenocarcinoma (Cell Line: HCC-2998)	[4]
Plicamycin + Topetecan	DC8KDA5	Plicamycin	Amelanotic melanoma (Cell Line: M14)	[4]
Plicamycin + Topetecan	DCPV4SI	Plicamycin	Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)	[4]
PMID28460551-Compound-2 + Topetecan	DCRUJLA	PMID28460551-Compound-2	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
PMID28460551-Compound-2 + Topetecan	DCF7K84	PMID28460551-Compound-2	Adenocarcinoma (Cell Line: OVCAR3)	[4]
PMID28460551-Compound-2 + Topetecan	DCVP7AR	PMID28460551-Compound-2	Adenocarcinoma (Cell Line: A549)	[4]
Pralatrexate + Topetecan	DCAJ35F	Pralatrexate	Astrocytoma (Cell Line: SNB-19)	[2]
Pralatrexate + Topetecan	DCQO62J	Pralatrexate	Renal cell carcinoma (Cell Line: SN12C)	[2]
Pralatrexate + Topetecan	DCSNVM4	Pralatrexate	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Pralatrexate + Topetecan	DC2TVTJ	Pralatrexate	Adenocarcinoma (Cell Line: OVCAR3)	[4]
Pralatrexate + Topetecan	DCBTYYB	Pralatrexate	Adenocarcinoma (Cell Line: A549)	[4]
Pralatrexate + Topetecan	DCH78PJ	Pralatrexate	Adenocarcinoma (Cell Line: HT29)	[4]
Pralatrexate + Topetecan	DC367PT	Pralatrexate	Adenocarcinoma (Cell Line: SW-620)	[4]
Pralatrexate + Topetecan	DCAATG2	Pralatrexate	Adenocarcinoma (Cell Line: HCT-15)	[4]
Pralatrexate + Topetecan	DC1FIWA	Pralatrexate	Adenocarcinoma (Cell Line: HCT116)	[4]
Pralatrexate + Topetecan	DCEE55F	Pralatrexate	Cutaneous melanoma (Cell Line: SK-MEL-5)	[4]
Pralatrexate + Topetecan	DC22M4D	Pralatrexate	Large cell lung carcinoma (Cell Line: NCI-H460)	[4]
Pralatrexate + Topetecan	DCTGGFL	Pralatrexate	Malignant melanoma (Cell Line: UACC62)	[4]
Pralatrexate + Topetecan	DC7JHHT	Pralatrexate	Melanoma (Cell Line: SK-MEL-2)	[4]
Raloxifene + Topetecan	DCJH9FQ	Raloxifene	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Raloxifene + Topetecan	DCJW8CD	Raloxifene	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Raloxifene + Topetecan	DCIGOI8	Raloxifene	Glioma (Cell Line: SF-539)	[2]
Raloxifene + Topetecan	DCFWK7G	Raloxifene	Carcinoma (Cell Line: MCF7)	[3]
Raloxifene + Topetecan	DC8XCYX	Raloxifene	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
Romidepsin + Topetecan	DCG54PP	Romidepsin	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Romidepsin + Topetecan	DC00EBZ	Romidepsin	Astrocytoma (Cell Line: U251)	[2]
Romidepsin + Topetecan	DCZVAEB	Romidepsin	Astrocytoma (Cell Line: SNB-19)	[2]
Romidepsin + Topetecan	DCMU2D5	Romidepsin	Clear cell renal cell carcinoma (Cell Line: CAKI-1)	[2]
Romidepsin + Topetecan	DCXNNBF	Romidepsin	Plasma cell myeloma (Cell Line: RPMI-8226)	[2]
Romidepsin + Topetecan	DC2KOP0	Romidepsin	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Romidepsin + Topetecan	DCYO5EA	Romidepsin	Adenocarcinoma (Cell Line: A549)	[4]
Romidepsin + Topetecan	DCHPJMY	Romidepsin	Cutaneous melanoma (Cell Line: SK-MEL-5)	[4]
Romidepsin + Topetecan	DCE96W5	Romidepsin	Large cell lung carcinoma (Cell Line: NCI-H460)	[4]
Romidepsin + Topetecan	DCP5X5A	Romidepsin	Lung adenocarcinoma (Cell Line: MDA-MB-231)	[4]
Romidepsin + Topetecan	DCRRSU7	Romidepsin	Lung adenocarcinoma (Cell Line: HOP-62)	[4]
Ruxolitinib + Topetecan	DCU01CA	Ruxolitinib	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Ruxolitinib + Topetecan	DCLH1C1	Ruxolitinib	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Sirolimus + Topetecan	DCKSZ9Q	Sirolimus	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Sirolimus + Topetecan	DCT1F3L	Sirolimus	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Sirolimus + Topetecan	DCEIK43	Sirolimus	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Sirolimus + Topetecan	DC9BF15	Sirolimus	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Sirolimus + Topetecan	DCQRGX8	Sirolimus	Glioma (Cell Line: SF-268)	[2]
Sirolimus + Topetecan	DCUT4OC	Sirolimus	Colon adenocarcinoma (Cell Line: COLO 205)	[3]
Sirolimus + Topetecan	DCH8LB6	Sirolimus	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Sirolimus + Topetecan	DCDYWWH	Sirolimus	Adenocarcinoma (Cell Line: A549)	[4]
Sirolimus + Topetecan	DCYZVQZ	Sirolimus	Adenocarcinoma (Cell Line: HCT116)	[4]
SY-1425 + Topetecan	DCWD7J7	SY-1425	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
SY-1425 + Topetecan	DCAVXNM	SY-1425	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
SY-1425 + Topetecan	DCW8OER	SY-1425	Glioma (Cell Line: SF-539)	[2]
SY-1425 + Topetecan	DCL7S6G	SY-1425	Adenocarcinoma (Cell Line: A549)	[4]
SY-1425 + Topetecan	DC0HM0C	SY-1425	Melanoma (Cell Line: MALME-3M)	[4]
Taxol + Topetecan	DCA4FNV	Taxol	Astrocytoma (Cell Line: SNB-19)	[2]
Taxol + Topetecan	DCOHVZ3	Taxol	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Taxol + Topetecan	DCL9ER5	Taxol	Glioma (Cell Line: SF-539)	[2]
Taxol + Topetecan	DCPM5VL	Taxol	Adenocarcinoma (Cell Line: A549)	[4]
Taxol + Topetecan	DCGTBXG	Taxol	Large cell lung carcinoma (Cell Line: NCI-H460)	[4]
Thioguanine + Topetecan	DC7QO5G	Thioguanine	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Thioguanine + Topetecan	DCG7RUR	Thioguanine	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Thioguanine + Topetecan	DCYM3LY	Thioguanine	Astrocytoma (Cell Line: U251)	[2]
Thioguanine + Topetecan	DCX00TP	Thioguanine	Glioma (Cell Line: SF-295)	[2]
Topetecan + GDC0941	DCXXTWQ	GDC0941	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Trametinib	DCO1OPG	Trametinib	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Carfilzomib	DC7L5BX	Carfilzomib	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Panobinostat	DC4CHYV	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Topetecan + Arsenic trioxide	DC40ZSH	Arsenic trioxide	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Topetecan + AZD8055	DCBY6C9	AZD8055	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Topetecan	DC6TTUR	Topetecan	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
Topetecan + TAK-733	DCMLVMG	TAK-733	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + GDC-0980/RG7422	DC7HYUH	GDC-0980/RG7422	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Mitomycin	DCN351T	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
Topetecan + OSI-027	DCH5GER	OSI-027	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Flavopiridol	DCQ7846	Flavopiridol	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + GSK2126458	DCT9J6N	GSK2126458	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Bortezomib	DCVYVBV	Bortezomib	Chronic myelogenous leukemia (Cell Line: K-562)	[2]
Topetecan + Obatoclax	DCCWSTG	Obatoclax	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Fenretinide	DCNVG79	Fenretinide	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Cisplatin	DCR5YGT	Cisplatin	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Topetecan + Cisplatin	DC6D9B6	Cisplatin	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Topetecan + Cisplatin	DC2CHXU	Cisplatin	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Topetecan + Cisplatin	DCNGB80	Cisplatin	Astrocytoma (Cell Line: SNB-19)	[2]
Topetecan + Cisplatin	DC22E3C	Cisplatin	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Topetecan + Podofilox	DCGRKOC	Podofilox	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Doxorubicin	DCFYI7I	Doxorubicin	Glioblastoma (Cell Line: JHH-136)	[2]
Topetecan + Ibrutinib	DCXXLHC	Ibrutinib	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
Topetecan + Arsenic trioxide	DC304H3	Arsenic trioxide	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Topetecan + Cisplatin	DC5FONV	Cisplatin	Carcinoma (Cell Line: RXF 393)	[3]
Topetecan + Cisplatin	DCZHIAX	Cisplatin	Colon adenocarcinoma (Cell Line: COLO 205)	[3]
Topetecan + Cisplatin	DCZD7EF	Cisplatin	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Topetecan + Ruxolitinib	DCZYPH3	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[4]
Topetecan + Arsenic trioxide	DCVVTLV	Arsenic trioxide	Adenocarcinoma (Cell Line: HCT116)	[4]
Topetecan + Arsenic trioxide	DCAHTFK	Arsenic trioxide	Melanoma (Cell Line: MALME-3M)	[4]
Topetecan + Arsenic trioxide	DCQUZTG	Arsenic trioxide	Melanoma (Cell Line: UACC-257)	[4]
Topetecan + Arsenic trioxide	DCQSQ8J	Arsenic trioxide	Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)	[4]
Topetecan + Bortezomib	DCXJB3T	Bortezomib	Amelanotic melanoma (Cell Line: M14)	[4]
Topetecan + Bortezomib	DC8C41J	Bortezomib	Lung adenocarcinoma (Cell Line: HOP-62)	[4]
Topetecan + Cisplatin	DCV6J8K	Cisplatin	Adenocarcinoma (Cell Line: DU-145)	[4]
Topetecan + Cisplatin	DCDUI9A	Cisplatin	Adenocarcinoma (Cell Line: OVCAR3)	[4]
Topetecan + Cisplatin	DCS0M4E	Cisplatin	Malignant melanoma (Cell Line: LOX IMVI)	[4]
Topetecan + Chlorambucil	DCBUDJA	Chlorambucil	High grade ovarian serous adenocarcinoma (Cell Line: OVCAR-4)	[4]
Topetecan + Chlorambucil	DC7F6WB	Chlorambucil	Malignant melanoma (Cell Line: LOX IMVI)	[4]
Topotecan + Topetecan	DCT2YGY	Topotecan	Carcinoma (Cell Line: MCF7)	[3]
Topotecan + Topetecan	DCCYOOW	Topotecan	Amelanotic melanoma (Cell Line: MDA-MB-435)	[4]
Topotecan + Topetecan	DCIF5CT	Topotecan	Clear cell renal cell carcinoma (Cell Line: CAKI-1)	[4]
Topotecan + Topetecan	DCY5XZM	Topotecan	Cutaneous melanoma (Cell Line: SK-MEL-28)	[4]
Topotecan + Topetecan	DCQP5WK	Topotecan	Lung adenocarcinoma (Cell Line: EKVX)	[4]
Topotecan + Topetecan	DCSFE3Z	Topotecan	Melanoma (Cell Line: MALME-3M)	[4]
Topotecan + Topetecan	DC6T63F	Topotecan	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
Topotecan + Topetecan	DCLDTZS	Topotecan	Mixed endometrioid and clear cell carcinoma (Cell Line: IGROV1)	[4]
Topotecan + Topetecan	DCKAVHX	Topotecan	Ovarian serous cystadenocarcinoma (Cell Line: SK-OV-3)	[4]
Topotecan + Topetecan	DCT4JUC	Topotecan	Papillary renal cell carcinoma (Cell Line: ACHN)	[4]
Topotecan + Topetecan	DCXPEK6	Topotecan	Pleural epithelioid mesothelioma (Cell Line: NCI-H226)	[4]
Triapine + Topetecan	DCAJRO6	Triapine	Amelanotic melanoma (Cell Line: M14)	[4]
Trifluridine + Topetecan	DCCNZFQ	Trifluridine	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Trifluridine + Topetecan	DCG12SZ	Trifluridine	Glioma (Cell Line: SF-295)	[2]
Trifluridine + Topetecan	DCO39F1	Trifluridine	Lung adenocarcinoma (Cell Line: EKVX)	[4]
Trifluridine + Topetecan	DCNAZV1	Trifluridine	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
Uracil mustard + Topetecan	DC7WOYW	Uracil mustard	Astrocytoma (Cell Line: U251)	[2]
Uracil mustard + Topetecan	DCWAR28	Uracil mustard	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Valrubicin + Topetecan	DCRXOVT	Valrubicin	Adult acute myeloid leukemia (Cell Line: HL-60(TB))	[2]
Valrubicin + Topetecan	DCJ0W9Z	Valrubicin	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Valrubicin + Topetecan	DCR2ZGS	Valrubicin	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Valrubicin + Topetecan	DCI4FS6	Valrubicin	Astrocytoma (Cell Line: U251)	[2]
Valrubicin + Topetecan	DC691R1	Valrubicin	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Valrubicin + Topetecan	DCFEDRA	Valrubicin	Invasive ductal carcinoma (Cell Line: T-47D)	[3]
Valrubicin + Topetecan	DCK7RJA	Valrubicin	Adenocarcinoma (Cell Line: DU-145)	[4]
Valrubicin + Topetecan	DCQJ14A	Valrubicin	Adenocarcinoma (Cell Line: NCIH23)	[4]
Valrubicin + Topetecan	DCM5MW2	Valrubicin	Adenocarcinoma (Cell Line: A549)	[4]
Valrubicin + Topetecan	DCBKJYY	Valrubicin	Adenocarcinoma (Cell Line: HCT116)	[4]
Vandetanib + Topetecan	DCVOLQX	Vandetanib	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[4]
Vandetanib + Topetecan	DC7P5K1	Vandetanib	Minimally invasive lung adenocarcinoma (Cell Line: NCI-H322M)	[4]
Vemurafenib + Topetecan	DCSW6FS	Vemurafenib	Anaplastic large cell lymphoma (Cell Line: SR)	[4]
Vincristine + Topetecan	DC89OAP	Vincristine	Childhood T acute lymphoblastic leukemia (Cell Line: CCRF-CEM)	[2]
Vinflunine + Topetecan	DC9FFUV	Vinflunine	Adult T acute lymphoblastic leukemia (Cell Line: MOLT-4)	[2]
Vinflunine + Topetecan	DCTVW0K	Vinflunine	Anaplastic large cell lymphoma (Cell Line: SR)	[2]
Vinflunine + Topetecan	DCFFC1Z	Vinflunine	Adenocarcinoma (Cell Line: SW-620)	[4]
Vismodegib + Topetecan	DC0EJ4Y	Vismodegib	Carcinoma (Cell Line: MCF7)	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 266 DrugCom(s)

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020671.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.