Details of the Drug Combinations

General Information of This Drug (ID: DMB4A8I)

Drug Name

MANOALIDE DMB4A8I

Synonyms

manoalide; UNII-E1DK0157K9; 75088-80-1; CHEMBL463914; CHEBI:66666; E1DK0157K9; 2(5H)-Furanone, 4-(3,6-dihydro-6-hydroxy-5-(4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-; 2(5H)-Furanone, 4-((2R,6R)-3,6-dihydro-6-hydroxy-5-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-, (5R)-; AC1O5NJS; SCHEMBL20551728; MolPort-020-000-975

Indication

Disease Entry	ICD 11	Status	REF
Arthritis	FA20	Phase 2	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
MANOALIDE + Lumefantrine	DC949M1	Lumefantrine	DD2 (Cell Line: DD2)	[2]
MANOALIDE + Diltiazem	DCFDFW4	Diltiazem	DD2 (Cell Line: DD2)	[2]
MANOALIDE + Mefloquine	DCM5JM9	Mefloquine	DD2 (Cell Line: DD2)	[2]
MANOALIDE + Lumefantrine	DC9BSMY	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
MANOALIDE + Diltiazem	DCGPK6C	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[3]
MANOALIDE + Chloroquine	DCBW6RU	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[3]
MANOALIDE + Mefloquine	DCR8TH7	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 DrugCom(s)

References

1	In situ aquaculture methods for Dysidea avara (Demospongiae, Porifera) in the northwestern Mediterranean. Mar Drugs. 2010 May 26;8(6):1731-42.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.