Details of the Drug Combinations

General Information of This Drug (ID: DMB4JPG)

Drug Name

CNTX-4975 DMB4JPG

Indication

Disease Entry	ICD 11	Status	REF
Knee osteoarthritis	FA01	Phase 3	[1]
Pain	MG30-MG3Z	Phase 3	[2]
Morton neuroma	8C11.6	Phase 2	[2]
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List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
CNTX-4975 + Panobinostat	DC7AWJ3	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
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References

1	ClinicalTrials.gov (NCT03660943) A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.