Details of the Drug Combinations

General Information of This Drug (ID: DMBAPFG)

• Drug Name: Brinzolamide (DMBAPFG)
• Synonyms: Azopt; Birnzolamide; Alcon brand of brinzolamide; Allphar brand of brinzolamide; Brinzolamide [USAN]; AL 4862; AL04862; BZ1; AL-4862; Azopt (TN); Brinzolamide (BRZ); Brinzolamide (JAN/USP/INN); (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide; 2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R

Indication

Ocular hypertension; ICD 11: 9C61.01; Status: Approved [1]; Open-angle glaucoma; ICD 11: 9C61; Status: Approved [2]

• Therapeutic Class: Antiglaucomic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Brinzolamide + Brimonidine	DCES7YX	Brimonidine	Glaucoma	[3]
Brinzolamide + Brimonidine	DCVY7EQ	Brimonidine	Open-Angle Glaucoma	[4]
Brinzolamide + Latanoprost	DC72YFX	Latanoprost	Ocular Hypertension	[5]

References

• [1] Brinzolamide FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6797).
• [3] ClinicalTrials.gov (NCT00800540) Circadian Ocular Perfusion Pressure and Ocular Blood Flow
• [4] ClinicalTrials.gov (NCT02339584) Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)
• [5] ClinicalTrials.gov (NCT01937312) Effect of SIMBRINZA Suspension as an Added Therapy to a Prostaglandin Analogue