Details of the Drug Combinations

General Information of This Drug (ID: DMC1I56)

Drug Name
Exherin   DMC1I56
Synonyms
Exherin; 229971-81-7; UNII-B058ME29VU; ADH-1; ADH1; B058ME29VU; ADH 1; ADH-1 pepide; Exherin (ADH-1); ADH-1;ADH1;ADH 1; SCHEMBL13857500; CHEMBL3818130; ZINC3939935; ADH-10001; AKOS030526741; CS-3450; L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-l-alanyl-L-valyl-, cyclic (1-5)-disulfide; HY-13541
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

37 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Exherin DC4EB9W (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + Exherin DCV1HGS ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
AT7519 + Exherin DC6MVUM AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
Cytarabine + Exherin DCCEMND Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + Exherin DCLNPHG Epothilone D Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + Exherin DCQWHFD Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + MK-1775 DCT3CJ1 MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Panobinostat DC4OB0I Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Exherin + Panobinostat DCBH3HS Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Eltanexor oral DCBX6KH Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Everolimus DCN8SVJ Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Lenvatinib DCM0Y6O Lenvatinib Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + SCH 727965 DC8YYKC SCH 727965 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + LY2523355 DC55N04 LY2523355 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + AEE-788 DCF6K2A AEE-788 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Mitomycin DCB4AIB Mitomycin Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + OSI-906 DC64Y23 OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Vincristine DCKZP5Y Vincristine Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Pelitinib DCPYHB2 Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + ABT-263 DCK0FAS ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Ispinesib DCN8AVV Ispinesib Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + (-)-englerin A DCSPJJD (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Decitabine DCOKKBD Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Romidepsin DC0ZMZ1 Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Doxorubicin DC1MQZ5 Doxorubicin Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + LY2874455 DCS2FMJ LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Cytarabine DCRZUF8 Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + CP-868596 DC3NBGU CP-868596 Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Ruxolitinib DCJDFU2 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
GDC-0084 + Exherin DC67WKW GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Exherin DC3Y0UZ JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
LY2874455 + Exherin DCJNDX2 LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + Exherin DC83TA1 MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
NVP-AUY922 + Exherin DCY989O NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
Panobinostat + Exherin DCRQFT1 Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
TG100801 + Exherin DCXDTGH TG100801 Ewing sarcoma (Cell Line: TC-71) [2]
THAPSIGARGIN + Exherin DC7TYPE THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 37 DrugCom(s)

References

1 ClinicalTrials.gov (NCT00264433) A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent. U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.