Details of the Drug Combinations

General Information of This Drug (ID: DMC4GEI)

Drug Name

Ospemifene DMC4GEI

Synonyms

Ospemifene; 128607-22-7; Osphena; FC-1271a; Deamino-hydroxytoremifene; Fc-1271; 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol; UNII-B0P231ILBK; CCRIS 9205; B0P231ILBK; CHEBI:73275; 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol; senshio; Ethanol, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-; 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}ethanol; Ophena; Ospemifene [USAN:INN:BAN]; Deaminotoremifene; Osphena (TN); Deaminohydroxytoremifene; AC1MI19T; C24H23ClO2

Indication

Disease Entry	ICD 11	Status	REF
Dyspareunia	GA12	Approved	[1]
Postmenopausal vaginal atrophy	GA30.2	Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

8 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ospemifene + DZNep	DCNX1FO	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[2]
Ospemifene + Panobinostat	DCQX78K	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Ospemifene + RG6046	DC5RZV3	RG6046	Lymphoid neoplasm (Cell Line: Mak)	[2]
Ospemifene + Idarubicin	DCWX9IU	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
Ospemifene + Sunitinib malate	DCH4M83	Sunitinib malate	Lymphoid neoplasm (Cell Line: Mak)	[2]
Ospemifene + Mizoribine	DC44YZX	Mizoribine	Lymphoid neoplasm (Cell Line: Mak)	[2]
Ospemifene + Colchicine	DCNWNE2	Colchicine	Lymphoid neoplasm (Cell Line: Mak)	[2]
Ospemifene + Ruxolitinib	DCV3UD5	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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⏷ Show the Full List of 8 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7349).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.