Details of the Drug Combinations

General Information of This Drug (ID: DMC4RNA)

Drug Name

TAK-733 DMC4RNA

Synonyms

TAK-733; 1035555-63-5; TAK733; TAK 733; UNII-5J61HSP0QJ; (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; 5J61HSP0QJ; CHEMBL1615025; 3-[(2r)-2,3-Dihydroxypropyl]-6-Fluoro-5-[(2-Fluoro-4-Iodophenyl)amino]-8-Methylpyrido[2,3-D]pyrimidine-4,7(3h,8h)-Dione; MLS006011054; SCHEMBL1528606; GTPL9911; DTXSID20648089; MolPort-023-293-497; RCLQNICOARASSR-SECBINFHSA-N; example 18 [US8470837]; AOB87182; EX-A2164; BCP06625

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ABT-263 + TAK-733	DCYLPJQ	ABT-263	Glioblastoma (Cell Line: JHH-136)	[2]
AS602868 + TAK-733	DCANRN8	AS602868	Glioblastoma (Cell Line: JHH-136)	[3]
AZD8055 + TAK-733	DCWC3E1	AZD8055	Glioblastoma (Cell Line: JHH-136)	[3]
Bardoxolone methyl + TAK-733	DC1PP2P	Bardoxolone methyl	Glioblastoma (Cell Line: JHH-136)	[3]
Flavopiridol + TAK-733	DCVESIK	Flavopiridol	Glioblastoma (Cell Line: JHH-136)	[3]
OSI-027 + TAK-733	DC1J0UP	OSI-027	Glioblastoma (Cell Line: JHH-136)	[3]
TAK-733 + Trametinib	DCJGW4L	Trametinib	Glioblastoma (Cell Line: JHH-136)	[3]
TAK-733 + Cladribine	DCM886U	Cladribine	Glioblastoma (Cell Line: JHH-136)	[3]
TAK-733 + Carfilzomib	DC8GO43	Carfilzomib	Glioblastoma (Cell Line: JHH-136)	[3]
TAK-733 + Panobinostat	DCSJGE3	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
TAK-733 + Ixazomib	DC4HPMP	Ixazomib	Glioblastoma (Cell Line: JHH-136)	[3]
TAK-733 + GDC-0980/RG7422	DCOHG9P	GDC-0980/RG7422	Glioblastoma (Cell Line: JHH-136)	[3]
TAK-733 + Idarubicin	DC3JR05	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
TAK-733 + GSK2126458	DC9QHDA	GSK2126458	Glioblastoma (Cell Line: JHH-136)	[3]
Topetecan + TAK-733	DCMLVMG	Topetecan	Glioblastoma (Cell Line: JHH-136)	[3]
Vorinostat + TAK-733	DCMKVV9	Vorinostat	Glioblastoma (Cell Line: JHH-136)	[3]
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⏷ Show the Full List of 16 DrugCom(s)

References

1	ClinicalTrials.gov (NCT00948467) Study of TAK-733 in Adult Patients With Advanced Nonhematologic Malignancies. U.S. National Institutes of Health.
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.