Details of the Drug Combinations

General Information of This Drug (ID: DMCDZ15)

• Drug Name: Evacetrapib (DMCDZ15)
• Synonyms: LY2484595

Indication

Cardiovascular disease; ICD 11: BA00-BE2Z; Status: Phase 3 [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

24 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
CA4P + Evacetrapib	DCR8V32	CA4P	Glioblastoma (Cell Line: JHH-136)	[2]
Evacetrapib + AT13387	DCXANF1	AT13387	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + JQ1	DC1K5OB	JQ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Carfilzomib	DCTTQD3	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Panobinostat	DCFFVAG	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Ixazomib	DCJW95V	Ixazomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Everolimus	DCPNUMK	Everolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Selumetinib	DCYVAQX	Selumetinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + SCH 727965	DCR4X1T	SCH 727965	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + THAPSIGARGIN	DC98C7R	THAPSIGARGIN	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Marizomib	DCQ5G4P	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Ridaforolimus	DCEF4AL	Ridaforolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + ONC201	DCJ8024	ONC201	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + PF-562271	DC92R11	PF-562271	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + CHS-828	DCWVYOT	CHS-828	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + THZ1	DC2M0UY	THZ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Bafilomycin A1	DCCEXIL	Bafilomycin A1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Mitapivat	DCAH30C	Mitapivat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Dasatinib	DCUX66F	Dasatinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Evacetrapib + Ruxolitinib	DCM488W	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
OSI-027 + Evacetrapib	DCDAEEB	OSI-027	Glioblastoma (Cell Line: JHH-136)	[2]
Panobinostat + Evacetrapib	DCL6E96	Panobinostat	Glioblastoma (Cell Line: JHH-136)	[2]
Tosyl-l-arginine methyl ester + Evacetrapib	DCY0WGU	Tosyl-l-arginine methyl ester	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Venglustat + Evacetrapib	DCV7D54	Venglustat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atorvastatin + Evacetrapib	DCZ5EEE	Atorvastatin	Hypercholesterolemia	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8401).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT02260648) A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia