Details of the Drug Combinations

General Information of This Drug (ID: DMCE5DP)

Drug Name

Elesclomol DMCE5DP

Synonyms

Elesclomol; 488832-69-5; Elesclomol (STA-4783); STA-4783; UNII-6UK191M53P; CHEBI:79369; 6UK191M53P; Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide]; 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid; N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; J-503879; C19H20N4O2S2; 1-N'-Benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl-oxopropanehydrazidide; Elesclomol [USAN:INN]; elesclomolum

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Artemisinin + Elesclomol	DCLLTBK	Artemisinin	DD2 (Cell Line: DD2)	[2]
Atovaquone + Elesclomol	DCYTP28	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[2]
Elesclomol + Mitomycin	DCS38EK	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
Elesclomol + Ibrutinib	DCHTMDS	Ibrutinib	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
Elesclomol + Ruxolitinib	DCRYDJ0	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
MK-3207 + Elesclomol	DCSCXOD	MK-3207	Hepatoblastoma (Cell Line: HB3)	[3]
Proguanil + Elesclomol	DCS4LSK	Proguanil	Hepatoblastoma (Cell Line: HB3)	[2]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	ClinicalTrials.gov (NCT00522834) Elesclomol (STA-4783) With Paclitaxel Versus Paclitaxel Alone in Melanoma. U.S. National Institutes of Health.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.