Details of the Drug Combinations

General Information of This Drug (ID: DMCHV4I)

Drug Name
Rifapentine   DMCHV4I
Synonyms
RIFAPENTINE; Rifapentina; Rifapentinum; Cyclopentylrifampicin; Rifamycin AF/ACPP; Antibiotic DL 473IT; KTC 1; 61379-65-5; MDL 473; DRG-0283; DL 473; R-773; R 77-3; 3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin; 3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV; 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin; Rifapentin,(S); NCGC00167431-01; ZINC169621228; NCGC00167431-03; AN-15578; RPE
Indication
Disease Entry ICD 11 Status REF
Pulmonary tuberculosis 1B10.Z Approved [1]
Tuberculosis 1B10-1B1Z Approved [2]
Macular degeneration 9B78.3 Investigative [3]
Therapeutic Class
Antituberculosis Agents
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Rifapentine + Panobinostat DCSY7EA Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [4]
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6 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Bedaquiline + Rifapentine DCE5ENS Bedaquiline Tuberculosis [5]
Isoniazid + Rifapentine DCRMHA9 Isoniazid HIV Infections [6]
Isoniazid + Rifapentine DCW9U5X Isoniazid Tuberculosis [7]
Rifapentine + Moxifloxacin DC81JE9 Moxifloxacin Mycobacterium Tuberculosis [8]
Rifapentine + Dolutegravir DCVAR5Q Dolutegravir Pediatric HIV Infection [9]
Isoniazid + Rifapentine DC5O6NC Isoniazid Tuberculosis, Pulmonary [10]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 Rifapentine FDA Label
2 Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
3 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 ClinicalTrials.gov (NCT02216331) PK Interaction Between Rifapentine or Rifampicin and a Single Dose of TMC207 in Healthy Subjects (TMC207-CL002)
6 ClinicalTrials.gov (NCT00057122) Tuberculosis Prevention for HIV Infected Adults
7 ClinicalTrials.gov (NCT01404312) Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB)
8 ClinicalTrials.gov (NCT00460759) Pharmacokinetic Issues of Moxifloxacin Plus Rifapentine
9 ClinicalTrials.gov (NCT06281834) Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention
10 ClinicalTrials.gov (NCT05454345) Sitafloxacin-containing Regimens for Shortening Tuberculosis Treatment