Details of the Drug Combinations

General Information of This Drug (ID: DMCU74R)

Drug Name
Daporinad   DMCU74R
Synonyms APO-866; FK-866; WK-175
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

28 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Daporinad DC09KZR (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
Abexinostat + Daporinad DC8PB73 Abexinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ABT-263 + Daporinad DCMP029 ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Daporinad DCP3NZV Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
CA4P + Daporinad DC0ML31 CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Carfilzomib + Daporinad DCKWR5V Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CHS-828 + Daporinad DCS2EXP CHS-828 Ewing sarcoma (Cell Line: TC-71) [2]
Daporinad + Carfilzomib DCEA2GQ Carfilzomib Ewing sarcoma (Cell Line: TC-71) [2]
Daporinad + Panobinostat DCXSJH4 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Daporinad + BN-2629 DCYT9Y8 BN-2629 Ewing sarcoma (Cell Line: TC-71) [2]
Daporinad + Parthenolide DCX99EW Parthenolide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Daporinad + SNDX-275 DC9E2W5 SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Daporinad + Niclosamide DCFHIGY Niclosamide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Daporinad + Prazosin DCBHSYQ Prazosin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Daporinad + Chloroquine DC76RVP Chloroquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Daporinad + CHS-828 DC6GF3C CHS-828 Ewing sarcoma (Cell Line: TC-71) [2]
Daporinad + Mefloquine DC6XEKJ Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Daporinad + Auranofin DC1SDH3 Auranofin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Decitabine + Daporinad DCRXZGH Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + Daporinad DCMEETU Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Larotrectinib + Daporinad DCK0EF9 Larotrectinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Lenvatinib + Daporinad DCX0WFU Lenvatinib Ewing sarcoma (Cell Line: TC-71) [2]
MK-1775 + Daporinad DCZ1UOA MK-1775 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PAC1 + Daporinad DCXQE8M PAC1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Pelitinib + Daporinad DCEBVGB Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
Rotenone + Daporinad DC25JOS Rotenone Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Trametinib + Daporinad DC3NWX3 Trametinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Withaferin A + Daporinad DCMUALI Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 28 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7745).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.