Details of the Drug Combinations

General Information of This Drug (ID: DMCX0K3)

• Drug Name: Cinacalcet (DMCX0K3)
• Synonyms: Cinacalcet [INN]; AMG 073; AMG073; Cinacalcet (USAN); Mimpara (TN); Sensipar (TN); N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine

Indication

Hyperparathyroidism; ICD 11: 5A51; Status: Approved [1]; Kidney disease; ICD 11: GC2Z; Status: Phase 3 [1]

• Therapeutic Class: Calcimimetics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

58 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Cinacalcet	DCOIHQ9	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Auranofin + Cinacalcet	DCVQXCF	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cerivastatin + Cinacalcet	DC7OZ7S	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Chlorzoxazone + Cinacalcet	DCNF5I2	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Triiodothyronine	DCHI660	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Gefitinib	DC648G4	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Terazosin	DCPE7PL	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Epinephrine	DCOA9YT	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + PMID28460551-Compound-2	DCLVDYD	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Methotrexate	DC5L5UW	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Fomepizole	DCUEPEK	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Acitretin	DCGXF2M	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Everolimus	DCCADZW	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Pepstatin	DC7K8QS	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Metyrosine	DCLB9OL	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Efavirenz	DCMMEJP	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Terameprocol	DCG4ORR	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Carglumic acid	DCQGKK4	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Docetaxel	DC1JVA0	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Fluspirilene	DCHIDZ8	Fluspirilene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + WAY-100635	DCQG7WE	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Zaleplon	DCBX7M7	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Eflornithine	DCZD9P6	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Tiagabine	DC6KQIM	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Entacapone	DCWO6RH	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Benserazide	DC1HJ9Z	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Methocarbamol	DC2V1T6	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Imatinib	DCUD3VK	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Bortezomib	DCNJGG9	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Methylene blue	DCXC8HJ	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Moricizine	DCM47CE	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Olanzapine	DC48RY4	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Trimethobenzamide	DCA6HXY	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Maprotiline	DC4RFEE	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Amiloride	DC13QZB	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Brincidofovir	DCIWMP1	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Mycophenolic acid	DCVIXS2	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Oxandrolone	DCHTEON	Oxandrolone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Cisatracurium	DCH8282	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Doxorubicin	DCY4GNS	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Nitisinone	DCZVK3Q	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Olmesartan medoxomil	DC9VQGO	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Atovaquone	DCI72JS	Atovaquone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Aciclovir	DCRRSOC	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cinacalcet + Cytarabine	DCJSCHT	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Citalopram + Cinacalcet	DCCFHYZ	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Diethylcarbamazine + Cinacalcet	DC4S9ET	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Hyodeoxycholic acid + Cinacalcet	DCGDEM0	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Idarubicin + Cinacalcet	DC1GLME	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Lefaxin + Cinacalcet	DCPKORF	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Levamisole + Cinacalcet	DC5DWHS	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mebutamate + Cinacalcet	DCMM4ER	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mefloquine + Cinacalcet	DCW46P3	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Miconazole + Cinacalcet	DCCILRU	Miconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mycophenolic acid + Cinacalcet	DCAHEE4	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Probenecid + Cinacalcet	DC0NAPU	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Spironolactone + Cinacalcet	DCK1C8F	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Vorinostat + Cinacalcet	DCJH9VU	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cinacalcet + Teriparatide	DCQET08	Teriparatide	Kidney Failure, Chronic	[3]
Cinacalcet + Amiloride	DCPVO7P	Amiloride	Primary Hyperparathyroidism	[4]
Cinacalcet + Eplerenone	DCQ7FUV	Eplerenone	Primary Hyperparathyroidism	[4]
Cinacalcet + Alendronate	DCXXBNE	Alendronate	Hyperparathyroidism, Primary	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3308).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT02440581) Renal Osteodystrophy: An Individual Management Approach
• [4] ClinicalTrials.gov (NCT02525796) Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism
• [5] ClinicalTrials.gov (NCT02417389) Efficacy of Cinacalcet in the Control of Primary Hyperparathyroidism