Details of the Drug Combinations

General Information of This Drug (ID: DMCYANK)

Drug Name
Doxapram   DMCYANK
Synonyms
Docatone; Dopram; Doxapramum; Doxapram HCL; Doxapram hydrochloride; Docatone (TN); Dopram (TN); Doxapram (INN); Doxapram [USP:JAN]; Doxapramum [INN-Latin]; (+-)-doxapram; 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone; 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one; 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one; 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-(9CI)
Indication
Disease Entry ICD 11 Status REF
Respiratory disease CB40 Approved [1]
Therapeutic Class
Central Nervous System Stimulants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

47 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abacavir + Doxapram DCIVGW5 Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Albendazole + Doxapram DCH8Q8E Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Doxapram DCLGL5D Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Doxapram DC7ERZ4 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Doxapram DCO28PY Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Busulfan + Doxapram DCEKLM8 Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + Doxapram DCBF2RN Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Doxapram DCL7APM Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Darunavir + Doxapram DC4X9RS Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + Doxapram DC65ERF Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dihydroergotamine + Doxapram DC5N21B Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Gefitinib DCR2XBJ Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Kanamycin DCW8NPD Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + PMID28460551-Compound-2 DC8RQ2S PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Methotrexate DCTE010 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Vinblastine DCLDQ0W Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Fomepizole DC2YMZZ Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Acitretin DCZKNSX Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Dronedarone DCP58LT Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Isosorbide dinitrate DCOZBC7 Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Docetaxel DCYNMLU Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Tiagabine DCZKXUE Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Maprotiline DC8OIJ9 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Leflunomide DCHAZD7 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Mycophenolic acid DCB0Y41 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Nitisinone DCY2DEZ Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Sumatriptan DC9WW1Z Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Rufinamide DCSN2OL Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Cerivastatin DC5KELI Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Doxapram DC1EXM5 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hydralazine + Doxapram DCITVR0 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + Doxapram DCYTD3A Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Doxapram DCKVUKN Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Doxapram DC3O3WZ JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Doxapram DCDP5GN Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Doxapram DCBFRP5 Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + Doxapram DC5HJBS Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pargyline + Doxapram DCZXQB8 Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Doxapram DCZ98EW PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Doxapram DC23KQU Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Doxapram DC3XNYI Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + Doxapram DCF4SOS Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Doxapram DC7RAQ5 Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Doxapram DCHIEMZ Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triamterene + Doxapram DCPG99M Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Doxapram DCUN9TE Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Doxapram DCNBFZG WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 47 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Doxapram + Theophylline DCPXHXW Theophylline Weaning Failure [3]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7169).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 ClinicalTrials.gov (NCT03894189) The Effect of Doxapram Versus Theophylline on Diaphragmatic Function