Details of the Drug Combinations

General Information of This Drug (ID: DMD6UKO)

Drug Name

Nedaplatin DMD6UKO

Synonyms

S-254; 254-S

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nedaplatin + Ruxolitinib	DCRMT9O	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
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5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nedaplatin + Irinotecan	DCEOETY	Irinotecan	Small Cell Lung Cancer	[3]
Nedaplatin + Docetaxel	DCQT035	Docetaxel	Esophageal Neoplasms	[4]
Nedaplatin + Vincristine	DCTG8ZX	Vincristine	Central Nervous System Tumors	[5]
Nedaplatin + Paclitaxel	DC0A5RR	Paclitaxel	Esophageal Neoplasms	[6]
Nedaplatin + Docetaxel	DCFVD5H	Docetaxel	Squamous Cell Carcinoma	[7]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	ClinicalTrials.gov (NCT01040312) An Observational Study of CPT-11 Plus Platinum Analogues Regimens and UGT1A1 Genotypes in Solid Tumors
4	ClinicalTrials.gov (NCT02429622) Simultaneous Integrated Boost Radiotherapy and Concurrent Chemotherapy for Locally Advanced Esophageal Carcinoma
5	ClinicalTrials.gov (NCT01735747) Temozolomide, Nedaplatin, Vincristine, and Radiotherapy as First-line Treatment in Newly Diagnosed Primary CNS Lymphoma
6	ClinicalTrials.gov (NCT02858206) Simultaneous Integrated Boost Radiotherapy and Concurrent Nimotuzumab or Chemotherapy for Esophageal Carcinoma
7	ClinicalTrials.gov (NCT02088515) Nedaplatin (Jiebaishu) Combined With Docetaxel for Advanced Lung Squamous Cell Carcinoma