Details of the Drug Combinations

General Information of This Drug (ID: DMD7L48)

Drug Name
Plinabulin   DMD7L48
Synonyms NPI-2358
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

23 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Crizotinib + Plinabulin DCVD6FO Crizotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Dasatinib + Plinabulin DCV3AMU Dasatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Doxorubicin + Plinabulin DCB3S91 Doxorubicin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-1775 + Plinabulin DC75EQG MK-1775 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + Plinabulin DC0YU19 ONC201 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PD-0325901 + Plinabulin DCWYGRN PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Piperaquine + Plinabulin DC1B89Z Piperaquine Glioblastoma (Cell Line: JHH-136) [2]
Plinabulin + Ruxolitinib DC1ZL13 Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
Plinabulin + Carfilzomib DC5WIAH Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Plinabulin + PMID28460551-Compound-2 DCSVK99 PMID28460551-Compound-2 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Plinabulin + Panobinostat DC06SWS Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Plinabulin + Selumetinib DCU8CWC Selumetinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Plinabulin + Triptolide DCWCZTG Triptolide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Plinabulin + Mitomycin DCYXR3J Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Plinabulin + Pelitinib DC0E12L Pelitinib Glioblastoma (Cell Line: JHH-136) [2]
Plinabulin + Flavopiridol DCF621M Flavopiridol Glioblastoma (Cell Line: JHH-136) [2]
Plinabulin + Podofilox DC8NJXE Podofilox Glioblastoma (Cell Line: JHH-136) [2]
Plinabulin + Vorinostat DC9ALM8 Vorinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Plinabulin + Ruxolitinib DCR5UI8 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Pyrazinamide + Plinabulin DCVHSTF Pyrazinamide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Ribavirin-TP + Plinabulin DC3KG4Y Ribavirin-TP Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Teriflunomide + Plinabulin DC84I2I Teriflunomide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THAPSIGARGIN + Plinabulin DCIUJ8G THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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⏷ Show the Full List of 23 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.