Details of the Drug Combinations

General Information of This Drug (ID: DME7VG6)

Drug Name

UK-383367 DME7VG6

Synonyms

UK 383367; 348622-88-8; UK-383367; CHEMBL226630; 5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide; (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide; ARJCBSRIPGJMAD-LLVKDONJSA-N; UK383367; 5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide; MLS006011234; SCHEMBL6430715; CTK8F1316; SYN3014; DTXSID30431303; MolPort-016-633-322; ZINC3818556; s2224; BDBM50216795; AKOS024458022; SB19579; RL03300; CS-0414

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
UK-383367 + Ruxolitinib	DCZM3BW	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
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References

1	Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically a... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6562-7.
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.