Details of the Drug Combinations

General Information of This Drug (ID: DMECBWN)

Drug Name
Riluzole   DMECBWN
Synonyms
Rilutek; Riluzol; Riluzolum; Riluzole HCl; RP 54274; ALBB-006046; BF-37; PK-26124; R-116; RP-54274; Rilutek (TN); Riluzol [INN-Spanish]; Riluzole [USAN:INN]; Riluzolum [INN-Latin]; ZERO/001785; Amino-2 trifluoromethoxy-6 benzothiazole; Amino-2 trifluoromethoxy-6 benzothiazole [French]; Riluzole (JAN/USAN/INN); PK-26124, RP-54274, Rilutek, Riluzole; 2-Amino-6-(trifluoromethoxy)-benzothiazole; 2-Amino-6-(trifluoromethoxy)benzothiazole; 2-Amino-6-trifluoro-methoxybenzothiazole; 2-amino-6-(trifluoromethoxy)-1,3-benzothiazole; 2-amino-6-(trifluoromethoxy)benzo[d]thiazole; 2-amino-6-(trifluoromethoxyl)benzothiazole; 2-amino-6-trifluoromethoxybenzothiazole; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine; 6-Trifluoromethoxy-benzothiazol-2-ylamine; 6-trifluoromethoxybenzothiazole-2-yl-amine
Indication
Disease Entry ICD 11 Status REF
Amyotrophic lateral sclerosis 8B60.0 Approved [1]
Therapeutic Class
Anticonvulsants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

8 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Ketamine + Riluzole DCTF6EK Ketamine Major Depression [2]
Memantine + Riluzole DCF92GK Memantine Mood [3]
Memantine + Riluzole DCN01SS Memantine Amyotrophic Lateral Sclerosis [4]
Sertraline + Riluzole DCEESEW Sertraline Major Depressive Disorder [5]
Ibudilast + Riluzole DCBEAF9 Ibudilast Amyotrophic Lateral Sclerosis [6]
MCI-186 + Riluzole DCQYRRG MCI-186 Neuromuscular Diseases [7]
Riluzole + Masitinib DCSL9MN Masitinib Amyotrophic Lateral Sclerosis (ALS) [8]
Riluzole + Masitinib DCGNGNK Masitinib Amyotrophic Lateral Sclerosis [9]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2326).
2 ClinicalTrials.gov (NCT00419003) Research Study for Major Depressive Disorder: Investigation of Glutamate Medications
3 ClinicalTrials.gov (NCT00283309) Memantine or Riluzole Prophylaxis for Corticosteroid-induced Mood and Declarative Memory Changes
4 ClinicalTrials.gov (NCT00353665) Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)
5 ClinicalTrials.gov (NCT01703039) Riluzole Augmentation Pilot in Depression (RAPID) Trial
6 ClinicalTrials.gov (NCT02238626) Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS)
7 ClinicalTrials.gov (NCT03272802) Treatment Effect of Edaravone in Patients With Amyotrophic Lateral Sclerosis (ALS)
8 ClinicalTrials.gov (NCT02588677) Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
9 ClinicalTrials.gov (NCT03127267) Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients