Details of the Drug Combinations

General Information of This Drug (ID: DMECRX1)

• Drug Name: Bivalirudin (DMECRX1)
• Synonyms: 128270-60-0; Angiomax; Hirulog; bivalirudinum; bivalirudina; Bivalirudin Trifluoroacetate; BG-8967; UNII-TN9BEX005G; BG8967; Bivalirudin Trifluoacetate; TN9BEX005G; D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine; CHEBI:59173; Hirulog-1; Angiox; Bivalirudina; Bivalirudine; Bivalirudinum; The Medicines Company brand of bivalirudin; BG 8967; Angiomax (TN); HS-2004; Bivalirudin [USAN:BAN:INN]; Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen; Phe-Pro-Arg-Pro-(Gly)4-desulfohirudin-(53-64); Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu

Indication

Thrombocytopenia; ICD 11: 3B64; Status: Approved [1]

• Therapeutic Class: Antithrombotic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aspirin + Bivalirudin	DCC89IY	Aspirin	Coronary Artery Disease	[2]
Aspirin + Bivalirudin	DC2KC8W	Aspirin	Coronary Artery Disease	[2]
Heparin + Bivalirudin	DCCAQT0	Heparin	Coronary Microvascular Disease	[3]
Heparin + Bivalirudin	DC11GZG	Heparin	Myocardial Infarction	[4]
Heparin + Bivalirudin	DCTIJK7	Heparin	Coronary Artery Disease	[5]
Prasugrel + Bivalirudin	DC4EIYJ	Prasugrel	Myocardial Infarction	[6]
Iodixanol + Bivalirudin	DCAGH8W	Iodixanol	Coronary Artery Disease	[7]
Ioxaglate + Bivalirudin	DCQUIF6	Ioxaglate	Coronary Artery Disease	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6470).
• [2] ClinicalTrials.gov (NCT02384070) Simplified Anti-Thrombotic Therapy for FFR
• [3] ClinicalTrials.gov (NCT03537586) A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
• [4] ClinicalTrials.gov (NCT00433966) Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction
• [5] ClinicalTrials.gov (NCT01464671) Angiomax or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention
• [6] ClinicalTrials.gov (NCT00976092) Efficacy Study of Combined Prasugrel and Bivalirudin Versus Clopidogrel and Heparin in Myocardial Infarction
• [7] ClinicalTrials.gov (NCT01848899) Effects Contrast on Platelet Activity, Thrombosis and Fibrinolysis in Patients Undergoing Coronary Angiography