Details of the Drug Combinations

General Information of This Drug (ID: DMEITAS)

Drug Name
SNS-032   DMEITAS
Synonyms
BMS-387032; BMS-387072; BMS-387032, SNS-032; N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide L-tartaric acid salt (2:1); N-(5-(((5-(1,1-Dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide; N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

12 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BMS-754807 + SNS-032 DCHSYPN BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + SNS-032 DCPGWTM CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dasatinib + SNS-032 DCW0PVU Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
MLN8237 + SNS-032 DCWFWE1 MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SCH 727965 + SNS-032 DCOENNU SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNS-032 + Ruxolitinib DCMA3HD Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
SNS-032 + PD-0325901 DC8JPE8 PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNS-032 + Mebendazole DC5QFAF Mebendazole Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNS-032 + IMD-0354 DCVF364 IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNS-032 + Prazosin DC2YO04 Prazosin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNS-032 + Mefloquine DC2Q6CM Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Trametinib + SNS-032 DC380M8 Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 12 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5670).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.