Details of the Drug Combinations

General Information of This Drug (ID: DMEOCKZ)

Drug Name
JZL195   DMEOCKZ
Synonyms JZL-195; JZL 195
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BHV-0223 + JZL195 DC6K6MV BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bumetanide + JZL195 DCA4285 Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + JZL195 DCX76V1 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + JZL195 DCY1E87 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dactinomycin + JZL195 DCPX3M1 Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diphenidol + JZL195 DCV4SRO Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + JZL195 DCUYKVC Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Everolimus + JZL195 DCW7FB1 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Galantamine + JZL195 DCSNNLQ Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Sertraline DC90REG Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Aliskiren DCH1EYU Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + PMID28460551-Compound-2 DC0R4Q7 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Tacrine DC20WTU Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Trioxsalen DCL6IQR Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Panobinostat DCZQ3Y8 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
JZL195 + Pazopanib HCl DCYZ6UN Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Methylergonovine DC69OAG Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Efavirenz DCTHAAJ Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Flavonoid derivative 1 DC3EMBC Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Doxapram DC3O3WZ Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Chlorzoxazone DCZ5UR1 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Phenprocoumon DCD5VXP Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Pazopanib DCAT4PK Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Daidzin DCIIIUH Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + VR-776 DCHQ61J VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Ciprofibrate DC9J2PA Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Nizatidine DCGAHSM Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + BIO-300 DCXT28N BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Trifluoperazine DC6B9I6 Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Diazoxide DCKUVHV Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Probenecid DCH55Z3 Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DC1N8AU 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Leflunomide DCVK9CO Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Brincidofovir DCZFNFF Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Pizotyline DCMTMTX Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Doxorubicin DC6SWY7 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Estramustine DC2G3A2 Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Cilostazol DCZ7H6H Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Ruxolitinib DCXVVUE Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
K-134 + JZL195 DCMZ0SU K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + JZL195 DCT8A8P Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LIAROZOLE + JZL195 DCKB290 LIAROZOLE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lithium Citrate + JZL195 DCQP1XF Lithium Citrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LY03004 + JZL195 DCDPLKW LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mecamylamine + JZL195 DCD6W7M Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + JZL195 DC918YN Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Memantine + JZL195 DCMZC4F Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + JZL195 DCI3OON Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + JZL195 DC5VDJS Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pargyline + JZL195 DC5A2GC Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + JZL195 DC7ZMSV Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + JZL195 DCL3FWI PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pomalidomide + JZL195 DC4A5LL Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + JZL195 DCEPCPT Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rufinamide + JZL195 DCNOX11 Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sitagliptin + JZL195 DCF25WJ Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + JZL195 DC0A9EE Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 57 DrugCom(s)

References

1 A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.