Details of the Drug Combinations

General Information of This Drug (ID: DMEOS5K)

Drug Name
AEE-788   DMEOS5K
Synonyms AEE; AEE 788; AEE788; GNF-Pf-5343; AEE-788, NVP-AEE 788, AEE788
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + AEE-788 DC1WK8E ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
AEE-788 + THAPSIGARGIN DCW1BPE THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [3]
Artemether + AEE-788 DCIFAXR Artemether Ewing sarcoma (Cell Line: TC-71) [3]
Etoposide + AEE-788 DCJII5O Etoposide Ewing sarcoma (Cell Line: TC-71) [3]
Everolimus + AEE-788 DCBDWNM Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
Exherin + AEE-788 DCF6K2A Exherin Ewing sarcoma (Cell Line: TC-71) [3]
LY2523355 + AEE-788 DC5HS0D LY2523355 Ewing sarcoma (Cell Line: TC-71) [3]
MK-1775 + AEE-788 DCCQCNC MK-1775 Ewing sarcoma (Cell Line: TC-71) [3]
PHA-739358 + AEE-788 DCU0E1D PHA-739358 Ewing sarcoma (Cell Line: TC-71) [3]
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⏷ Show the Full List of 9 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Everolimus + AEE-788 DCZU17G Everolimus Brain and Central Nervous System Tumors [4]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7643).
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT00107237) AEE788 and Everolimus in Treating Patients With Recurrent or Relapsed Glioblastoma Multiforme