Details of the Drug Combinations

General Information of This Drug (ID: DMEXWWV)

• Drug Name: Bromhexine (DMEXWWV)
• Synonyms: Bromhexine hydrochloride; 611-75-6; Bromhexine HCl; Auxit; Bromohexine hydrochloride; Viscolyt; Bisolvon; Broncokin; Bromhexine chloride; Quentan; UNII-YC2ZOM3Z8V; Bromhexine (hydrochloride); Bromohexine monohydrochloride; 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride; YC2ZOM3Z8V; CHEBI:31303; NCGC00095005-01; AK163668; N-(2-Amino-3,5-dibromobenzyl)-N-methyl-cyclohexylammonium chloride; 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride

Indication

Sjogren syndrome; ICD 11: 4A43.20; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bromhexine + Ruxolitinib	DCNPQ8P	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bromhexine + Hydroxychloroquine	DCCDYTY	Hydroxychloroquine	Hydroxychloroquine	[3]
Bromhexine + Hydroxychloroquine	DCWHDEZ	Hydroxychloroquine	Coronavirus Disease 2019 (COVID-19)	[4]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [3] ClinicalTrials.gov (NCT04340349) Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
• [4] Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia