Details of the Drug Combinations

General Information of This Drug (ID: DMF57DM)

Drug Name
Pazopanib   DMF57DM
Synonyms
Pazopanib; Pazopanib (GW-786034); 444731-52-6; 5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide; 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide; 5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide; 790713-33-6; 7RN5DR86CK; CHEBI:71219; DSSTox_CID_28659; DSSTox_GSID_48733; DSSTox_RID_82929; GW 78603; GW 786034; GW-786034; GW786034; MFCD11616589; NCGC00188865-01; UNII-7RN5DR86CK
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

90 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Pazopanib DCY8GED Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Acetazolamide + Pazopanib DCBQKY0 Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Aciclovir + Pazopanib DCYW2DT Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Aminosalicylic acid + Pazopanib DCHKA22 Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Amodiaquine + Pazopanib DCVQHXB Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Asenapine + Pazopanib DC0YLU5 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Bosentan + Pazopanib DCX0KT7 Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Brincidofovir + Pazopanib DC47CEX Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Busulfan + Pazopanib DCWLDIE Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Chlormezanone + Pazopanib DCHPYOR Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Chlorzoxazone + Pazopanib DCLZM7P Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Cilastatin + Pazopanib DCIAJUM Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Cisatracurium + Pazopanib DCTLK74 Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Citalopram + Pazopanib DC7HGLS Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Eflornithine + Pazopanib DCUBLEX Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Estramustine + Pazopanib DCTGWSY Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Etomidate + Pazopanib DC2L2RW Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Fenoprofen + Pazopanib DC7RK5I Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Fomepizole + Pazopanib DC1QGVA Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Gefitinib + Pazopanib DCE8HQP Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
GINKGOLIDE A + Pazopanib DCULHXZ GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
GS4071 + Pazopanib DC1JWE3 GS4071 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Guanfacine + Pazopanib DCUI0P2 Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Hydralazine + Pazopanib DCAMJ4C Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Imatinib + Pazopanib DCZSD7R Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
IT-141 + Pazopanib DCCMQY6 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
JZL195 + Pazopanib DCAT4PK JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
K-134 + Pazopanib DCUX71P K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Leflunomide + Pazopanib DC91PHM Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Lubiprostone + Pazopanib DCGLYKA Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Mefloquine + Pazopanib DC4C7KQ Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Mycophenolic acid + Pazopanib DCSNNIT Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Naltrexone + Pazopanib DCWEANX Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Norcisapride + Pazopanib DCCB1UC Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Oxyphenbutazone + Pazopanib DC9HET2 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Aprepitant DC589T8 Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Lefaxin DC7QE7F Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Bepridil DCDQJGP Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Diethylcarbamazine DCTUV71 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Panobinostat DCWJ4US Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
Pazopanib + Pazopanib HCl DC2IFKJ Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Acitretin DCSC8U0 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Tranexamic acid DCXU4EY Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Rifampin DCLMCH1 Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Palonosetron DCFERFW Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Testosterone cypionate DCJQYXA Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Emetine DCNBMVX Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Ursodeoxycholic acid DC81M9X Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Docetaxel DCTJBDZ Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Marizomib DCUX937 Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [1]
Pazopanib + Ginsenoside Rb1 DCO6AJX Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Daidzin DCGQ4U9 Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Fluspirilene DCS62DN Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Naringenin DCMJBZH Naringenin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Clopidogrel DCPLC58 Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Diphenidol DCYALCC Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + BIO-300 DCNYA6M BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Isoproterenol DCXZGA7 Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Ibutilide DCJFO90 Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Diazoxide DCM5OGP Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Idarubicin DCHAL3X Idarubicin Glioblastoma? (Cell Line: T98G) [1]
Pazopanib + Methylene blue DCTQTN0 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Artemisinin DC9KJUY Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Maprotiline DC9QF8D Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DC4USQB 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Novobiocin DCH34NK Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Hyodeoxycholic acid DCZYOJZ Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Quinine DCJRFRI Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Spironolactone DCDV4R2 Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Lacosamide DCPA3RT Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Doxorubicin DCASV72 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Auranofin DCZOPZN Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Vorinostat DCMKVFI Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Cerivastatin DCR1G9S Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Metaxalone DCQKB15 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pazopanib + Albendazole DCA8H4Q Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pentamidine + Pazopanib DCEYXF5 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Picoplatin + Pazopanib DC4M2UO Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Pinacidil + Pazopanib DCBAR2U Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
PMID28460551-Compound-2 + Pazopanib DC61OAT PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Ramelteon + Pazopanib DCFXEIG Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Repaglinide + Pazopanib DCT4ETA Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Sivelestat + Pazopanib DCLBYGV Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Sumatriptan + Pazopanib DC0WI4R Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Theophylline + Pazopanib DCTXXWM Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Topotecan + Pazopanib DCLJ83O Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Pazopanib DCTF764 Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Valproic Acid + Pazopanib DCZV2GR Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
Vinblastine + Pazopanib DC0TNYV Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
VR-776 + Pazopanib DCJB0ZS VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [1]
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⏷ Show the Full List of 90 DrugCom(s)
31 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Crizotinib + Pazopanib DCXW0I5 Crizotinib Advanced Cancers [3]
Docetaxel + Pazopanib DC6DYV3 Docetaxel Neoplasms, Breast [4]
Docetaxel + Pazopanib DCE8F5T Docetaxel Neoplasms, Breast [4]
Erlotinib + Pazopanib DC2MGUV Erlotinib Lung Cancer, Non-Small Cell [5]
Everolimus + Pazopanib DC3BTFP Everolimus Solid Tumor [6]
Gemcitabine + Pazopanib DC3XER7 Gemcitabine Lung Cancer, Non-Small Cell [7]
Gemcitabine + Pazopanib DCKDMR5 Gemcitabine Bladder Cancer [8]
Ifosfamide + Pazopanib DC7YBSY Ifosfamide Non-rhabdomyosarcoma [9]
Ixabepilone + Pazopanib DC17RJ7 Ixabepilone Breast Cancer [10]
Lapatinib + Pazopanib DCR384Z Lapatinib Carcinoma, Renal Cell [11]
Pazopanib + Pemetrexed DC0DM1I Pemetrexed Lung Cancer, Non-Small Cell [5]
Pazopanib + Topotecan DC0ZSZ6 Topotecan Gynecologic Tumors [12]
Pazopanib + Tivantinib DC3ZEMK Tivantinib Solid Tumor [13]
Pazopanib + Carboplatin DC62NA8 Carboplatin Cancer, Metastatic [14]
Pazopanib + Vinorelbine DCC2KU5 Vinorelbine Metastatic Non Small Cell Lung Cancer [15]
Pazopanib + Epirubicin DCFHKL4 Epirubicin Neoplasms, Breast [16]
Pazopanib + Paclitaxel DCFLA2D Paclitaxel Bladder Cancer [17]
Pazopanib + Topotecan DCHNPYR Topotecan Solid Tumours [18]
Pazopanib + MLN8237 DCL2I32 MLN8237 Malignant Neoplasm of Breast [19]
Pazopanib + Moxifloxacin DCWOC84 Moxifloxacin Carcinoma, Renal Cell [20]
Pazopanib + Vorinostat DCY9U4L Vorinostat Advanced Cancer [21]
Pazopanib + Merimepodib DCEOJQ4 Merimepodib Inflammatory breast cancer [22]
Pazopanib + Temozolomide DCTHJOF Temozolomide Sarcoma [23]
Sunitinib + Pazopanib DC3R7O5 Sunitinib Carcinoma, Renal Cell [24]
Trametinib + Pazopanib DCK3TSF Trametinib Solid Tumors [25]
Pazopanib + Trabectedin DCQH35C Trabectedin Locally Advanced Uterine Corpus Leiomyosarcoma [26]
Pazopanib + Paclitaxel DCUEB5Z Paclitaxel Ovarian Cancer [27]
Sunitinib + Pazopanib DC38BKC Sunitinib Metastatic Renal Cell Carcinoma [28]
Trametinib + Pazopanib DCG7XD7 Trametinib Gastrointestinal Stromal Tumors [29]
Abexinostat + Pazopanib DCTFW03 Abexinostat Renal Cell Carcinoma [30]
Eribulin + Pazopanib DCOST64 Eribulin Sarcoma,Soft Tissue [31]
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⏷ Show the Full List of 31 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 ClinicalTrials.gov (NCT01548144) Pazopanib or Pemetrexed and Crizotinib in Advanced Cancer
4 ClinicalTrials.gov (NCT00388076) Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB)
5 ClinicalTrials.gov (NCT00619424) A Phase I Study Of Pazopanib With Either Erlotinib Or Pemetrexed In Patients With Advanced Solid Tumors
6 ClinicalTrials.gov (NCT01184326) Expanded Phase I Pazopanib and Everolimus in Advanced Solid Tumors and Previously Treated Advanced Urothelial Cancer
7 ClinicalTrials.gov (NCT00678977) A Phase I, Open-label, Study of Pazopanib in Combination With Gemcitabine and Gemcitabine Plus Cisplatin for Advanced Solid Tumors
8 ClinicalTrials.gov (NCT01622660) Gemcitabine and Pazopanib in Chemotherapy Nave Patients With Advanced/Metastatic Urothelial Carcinoma Ineligible for Cisplatin-based Chemotherapy
9 ClinicalTrials.gov (NCT06239272) NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
10 ClinicalTrials.gov (NCT01012362) Study of Pazopanib and Ixabepilone in Patients With Solid Tumors
11 ClinicalTrials.gov (NCT00158782) Study Of Safety And Tolerability Of GW786034 Given With Lapatinib In Cancer Patients
12 ClinicalTrials.gov (NCT00800345) Phase I Trial of Oral Metronomic Topotecan and Oral Pazopanib to Treat Recurrent/Persistent Gynecologic Tumors
13 ClinicalTrials.gov (NCT01468922) Pazopanib and ARQ 197 for Advanced Solid Tumors
14 ClinicalTrials.gov (NCT01542047) A Combination of Pazopanib and Carboplatin in Advanced Solid Malignancies
15 ClinicalTrials.gov (NCT01060514) Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer
16 ClinicalTrials.gov (NCT00722293) A Phase I, Open-label, Study of Pazopanib in Combination With Epirubicin or Doxorubicin for Advanced Solid Tumors
17 ClinicalTrials.gov (NCT01108055) Phase II Pazopanib in Combination With Weekly Paclitaxel in Refractory Urothelial Cancer
18 ClinicalTrials.gov (NCT00732420) Open-label Study of Topotecan and Pazopanib in Advanced Solid Tumors
19 ClinicalTrials.gov (NCT01639911) Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors
20 ClinicalTrials.gov (NCT00861029) VEG111485: A QTc Study of Pazopanib
21 ClinicalTrials.gov (NCT01339871) Study of Pazopanib and Vorinostat in Patients With Advanced Malignancies
22 A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2+ inflammatory breast cancer. Breast Cancer Res Treat. 2013 Jan;137(2):471-82.
23 ClinicalTrials.gov (NCT03139331) PAZIT Study for Children and Young Adults With Relapsed or Refractory Sarcoma
24 ClinicalTrials.gov (NCT01064310) Patient Preference Study of Pazopanib Versus Sunitinib in Advanced or Metastatic Kidney Cancer
25 ClinicalTrials.gov (NCT01438554) Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma
26 ClinicalTrials.gov (NCT05432791) Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working
27 ClinicalTrials.gov (NCT02383251) Paclitaxel/Pazopanib for Platinum Resistant/Refractory Ovarian Cancer
28 ClinicalTrials.gov (NCT02959554) Study in Which Therapy is Either Switched to Nivolumab After 3 Months of Treatment or Therapy is Continued With a Tyrosine Kinase Inhibitor in Patients With Metastatic Renal Cell Carcinoma (RCC) and Disease Control
29 ClinicalTrials.gov (NCT02342600) SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)
30 ClinicalTrials.gov (NCT03592472) A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV). U.S. National Institutes of Health.
31 ClinicalTrials.gov (NCT06263231) A Study to Investigate Efficacy & Safety of INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)