General Information of This Drug (ID: DMFDC0Q)

Drug Name
Tiotropium   DMFDC0Q
Synonyms
186691-13-4; UNII-0EB439235F; 0EB439235F; [3H]tiotropium; (1r,2r,4s,5s,7s)-7-{[hydroxy(Dithiophen-2-Yl)acetyl]oxy}-9,9-Dimethyl-3-Oxa-9-Azoniatricyclo[3310~2,4~]nonane; NCGC00167971-01; 0HK; (1R,2R,4S,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3310^{2,4}]nonan-9-ium; GTPL367; SCHEMBL4662461; GTPL8592; DTXSID5044281; CHEMBL3305968; Spiriva (TN); Tiotropium bromide [USAN:INN]; (1A,2A,4A,5A,7A)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatri-cyclo[331024]nonane bromide; (1a,2,4,5a,7)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[33102,4]nonane bromide; 7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[33102,4]nonane bromide
Indication
Disease Entry ICD 11 Status REF
Chronic obstructive pulmonary disease CA22 Approved [1]
Pulmonary emphysema CA21.Z Approved [2]
Asthma CA23 Investigative [2]
Therapeutic Class
Bronchodilator Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Olodaterol + Tiotropium DC9SWB7 Olodaterol Pulmonary Disease, Chronic Obstructive [3]
Tiotropium + Indacaterol DC2KP8U Indacaterol Chronic Obstructive Pulmonary Disease (COPD) [4]
Tiotropium + Salbutamol DCD2NNT Salbutamol Chronic Obstructive Pulmonary Disease [5]
Ciclesonide + Tiotropium DC477CF Ciclesonide Pulmonary Disease, Chronic Obstructive [6]
Tiotropium + Fluticasone DCHRRAY Fluticasone Pulmonary Disease, Chronic Obstructive [6]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 367).
2 Tiotropium FDA Label
3 ClinicalTrials.gov (NCT01694771) Co-administration of Olodaterol Respimat and Tiotropium Handihaler
4 ClinicalTrials.gov (NCT00615459) A Crossover Study to Determine the Effect on Lung Function of Indacaterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Using Tiotropium as an Active Control
5 ClinicalTrials.gov (NCT01120691) Effect of QVA149 Versus NVA237 and Tiotropium on Chronic Obstructive Pulmonary Disorder (COPD) Exacerbations
6 ClinicalTrials.gov (NCT00535366) Efficacy and Safety Comparison of Steroid or Placebo in Combination With Salmeterol and Tiotropium in COPD