Details of the Drug Combinations

General Information of This Drug (ID: DMFMRN8)

Drug Name
18beta-Glycyrrhetic acid   DMFMRN8
Synonyms
18b-Glycyrrhetic acid; CHEMBL208873; 18b-Glycyrrhetinic acid; Glycyrrhetinic Acid, 8; 18; A-Glycyrrhetintic Acid; SCHEMBL231125; BDBM23195; pentacyclic triterpene compound 8; MolPort-023-220-126; AKOS016009607; cent-GLYCYRRHETINTIC ACID; AS-11631; SC-17800; (2S,4aS,6aS,6bR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
18beta-Glycyrrhetic acid + Ruxolitinib DC6B2YP Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
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1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Dexamethasone + 18beta-Glycyrrhetic acid DCZCJPP Dexamethasone Immune Thrombocytopenia [3]
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References

1 Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 ClinicalTrials.gov (NCT03998982) Glycyrrhetinic Acid Combined With Dexamethasone in Management of Newly Diagnosed ITP