Details of the Drug Combinations

General Information of This Drug (ID: DMFZBNE)

Drug Name

ITF2357 DMFZBNE

Synonyms

Givinostat; Carbamic acid, N-(4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl ester, hydrochloride (1:1)

Indication

Disease Entry	ICD 11	Status	REF
Duchenne dystrophy	8C70	Phase 3	[1]
Essential thrombocythemia	3B63.1Z	Phase 2	[2]
Myelofibrosis	2A20.2	Phase 2	[2]
Polycythemia vera	2A20.4	Phase 2	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clarithromycin + ITF2357	DCIJMM2	Clarithromycin	Drug-Drug Interaction	[3]
Clarithromycin + ITF2357	DCN2HZT	Clarithromycin	Drug Drug Interaction	[4]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7490).
3	ClinicalTrials.gov (NCT05492318) Perpetrator DDI Potential of Givinostat as Inhibitor and Inducer of CYP3A and P-gp Activity
4	ClinicalTrials.gov (NCT05845567) The Potential of Givinostat as DDI Victim in Co-administration P-gp Inhibitor (Part 2)