Details of the Drug Combinations

General Information of This Drug (ID: DMGINBT)

Drug Name

SGC707 DMGINBT

Synonyms

1687736-54-4; SGC 707; SGC-707; 1-Isoquinolin-6-Yl-3-[2-Oxo-2-(Pyrrolidin-1-Yl)ethyl]urea; GTPL8552; KS-00000THM; AOB5757; MolPort-039-101-300; EX-A1304; BCP16746; s7832; ZINC220951188; AKOS025142099; CS-5370; ACN-053041; NCGC00384204-04; HY-19715; AK546586; SGC707, > AS-16917; FT-0700238; J-690235; 1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea; 1-(isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea; 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
SGC707 + Carfilzomib	DCW7BAL	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
SGC707 + Mebendazole	DCPZNS8	Mebendazole	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
SGC707 + Rotenone	DCXZZLY	Rotenone	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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References

1	A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.