Details of the Drug Combinations

General Information of This Drug (ID: DMGXENV)

• Drug Name: Saxagliptin (DMGXENV)
• Synonyms: Onglyza; BMS 477118-11; BMS-477118; Kombiglyze XR (TN); OPC-262; Onglyza (TN); BMS-477118-11; (1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3

Indication

Type-2 diabetes; ICD 11: 5A11; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dapagliflozin + Saxagliptin	DC42707	Dapagliflozin	Type 2 Diabetes Mellitus	[2]
Metformin + Saxagliptin	DCJZJ9F	Metformin	Type 2 Diabetes	[3]
Metformin + Saxagliptin	DCY4K9C	Metformin	Type 2 Diabetes Mellitus	[4]
Sildenafil + Saxagliptin	DC3X8FD	Sildenafil	Diabetes Mellitus, Type 2	[5]
Saxagliptin + Acarbose	DCTED2T	Acarbose	Type 2 Diabetes	[6]
Glimepiride + Saxagliptin	DCX4F13	Glimepiride	Type 2 Diabetes	[7]
Saxagliptin + Saxagliptin	DCEB4LO	Saxagliptin	Diabetes Mellitus, Non-Insulin-Dependent	[8]
Saxagliptin + Exenatide	DC5KBFV	Exenatide	Prediabetes	[9]
Saxagliptin + Acarbose	DCIF1RC	Acarbose	Type 2 Diabetes Mellitus	[10]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6316).
• [2] ClinicalTrials.gov (NCT01662999) Drug Interaction Study of Saxagliptin in Combination With Dapagliflozin in Healthy Participants
• [3] ClinicalTrials.gov (NCT00661362) Evaluate Efficacy and Safety of Saxagliptin in Combination With Metformin in Adult Patients With Type 2 Diabetes
• [4] ClinicalTrials.gov (NCT00897390) Bioequivalence Study of Saxagliptin and Glucophage Combination Formulations in Healthy Subjects (B)
• [5] ClinicalTrials.gov (NCT04170790) Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy Volunteers
• [6] ClinicalTrials.gov (NCT02315495) Combining Saxagliptin and Acarbose to Improve Postprandial Glycaemia in Type 2 Diabetes
• [7] ClinicalTrials.gov (NCT02280486) Efficacy and Safety of Saxagliptin VS. Glimepiride in Chinese T2DM Patients Controlled Inadequately With Metformin
• [8] ClinicalTrials.gov (NCT02481479) Saxagliptin and Cardiac Structure and Function
• [9] ClinicalTrials.gov (NCT02104739) Effects of Antidiabetic Medications on the Postprandial State in Prediabetes
• [10] ClinicalTrials.gov (NCT02605772) Safety and Efficacy of Acarbose+Saxagliptin Compared With Metformin+Saxagliptin in Patients With Type 2 Diabetes