Details of the Drug Combinations

General Information of This Drug (ID: DMGYBZI)

Drug Name
PHA-739358   DMGYBZI
Synonyms Danusertib; PHA 739358; Danusertib, PHA-739358; (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide; 5-Amido-pyrrolopyrazole 9d
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

90 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + PHA-739358 DCES5N8 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + PHA-739358 DC6PNZB ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
Acamprosate + PHA-739358 DCWOS2Z Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Allopurinol + PHA-739358 DCACD9N Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aminosalicylic acid + PHA-739358 DC9EVCH Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + PHA-739358 DC71KSZ Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Artemether + PHA-739358 DC6GP68 Artemether Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + PHA-739358 DCUWCSH AZD8055 Ewing sarcoma (Cell Line: TC-71) [2]
Bardoxolone methyl + PHA-739358 DCGLPXS Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
Bortezomib + PHA-739358 DCUKELO Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + PHA-739358 DCQOC55 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cantharidin + PHA-739358 DCOKDPI Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
Chlorambucil + PHA-739358 DCOFGOG Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlormezanone + PHA-739358 DCSP84J Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + PHA-739358 DC0PE76 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ciprofibrate + PHA-739358 DCC3YPZ Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Desoxycorticosterone pivalate + PHA-739358 DC67P5L Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dichlorphenamide + PHA-739358 DC42T51 Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dopamine + PHA-739358 DCIA3K4 Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Everolimus + PHA-739358 DC0UU84 Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Fenoprofen + PHA-739358 DCGDJW5 Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Formononetin + PHA-739358 DCG4THV Formononetin Ewing sarcoma (Cell Line: TC-71) [2]
GSK2194069 + PHA-739358 DCW61BS GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + PHA-739358 DCHJ6FX Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JQ1 + PHA-739358 DCDNYYN JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
Levamisole + PHA-739358 DCEI2H7 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Loperamide + PHA-739358 DCCAQXT Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LY2874455 + PHA-739358 DCJJJ0I LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Methylene blue + PHA-739358 DC0BMQK Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
MK-2206 + PHA-739358 DCUBO0O MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
Mycophenolic acid + PHA-739358 DC5BRUU Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
NITD609 + PHA-739358 DCAFFIJ NITD609 Hepatoblastoma (Cell Line: HB3) [3]
OSI-906 + PHA-739358 DCSYQOR OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
Panobinostat + PHA-739358 DCZOIC1 Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + PHA-739358 DCDKE7G Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Sertraline DCKWOXA Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Mebutamate DCPWX6O Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Primidone DCNPV6I Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Gefitinib DCGQSI1 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Dantrolene DCIF1VV Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Diethylcarbamazine DCLRWQS Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Buparlisib DC98ET9 Buparlisib Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Triamterene DCHKQAN Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Epinephrine DCMEKF0 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Panobinostat DC9DSK9 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PHA-739358 + Panobinostat DCTZI04 Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Anamorelin DCUPH3G Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Eltanexor oral DCO5UR3 Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Ramelteon DCI8OQR Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + GDC-0084 DCP4NIQ GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + BHV-0223 DCWO2J8 BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Testosterone cypionate DCTWZSP Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + THAPSIGARGIN DCWB9NV THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + LY03004 DCRDY2Y LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + JZL195 DCL3FWI JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + AEE-788 DCU0E1D AEE-788 Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + WAY-100635 DCYDEO9 WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + BIO-300 DCL5XG5 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Diazoxide DCI64AN Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Benserazide DCAR5JF Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Idarubicin DC1SUTE Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Idarubicin DC3T9ZY Idarubicin Glioblastoma? (Cell Line: T98G) [2]
PHA-739358 + Probenecid DCV2AHL Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + ABT-263 DC031MX ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Mebendazole DC5NOXV Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Bardoxolone methyl DCOGSTJ Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Olanzapine DCFNZR7 Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Enalaprilat DCVXCF3 Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Maprotiline DCNO35I Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Teriflunomide DCV7TKZ Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Decitabine DCM5ZWN Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Leflunomide DC1Z3XH Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Hyodeoxycholic acid DCTMJ8P Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Romidepsin DCGTJMP Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + CHS-828 DCID0R0 CHS-828 Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + NVP-AUY922 DCN1BL7 NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
PHA-739358 + Mefloquine DCNYP4X Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Doxorubicin DCKJ6NI Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Zileuton DC0UJFJ Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Sumatriptan DCMXNXG Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Auranofin DCSE9P1 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Vorinostat DC8QRXW Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Cerivastatin DCDHDM4 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Cytarabine DCD1J2P Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Cytarabine DC5FPRU Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
SCH 727965 + PHA-739358 DC1P13M SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + PHA-739358 DC5EM35 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + PHA-739358 DCXKQZQ Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + PHA-739358 DCQXO1D Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triflupromazine + PHA-739358 DCULX4Y Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7937).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.