Details of the Drug Combinations

General Information of This Drug (ID: DMH1M9B)

• Drug Name: Benazepril (DMH1M9B)
• Synonyms: Benazapril; Benazeprilum; Benzazepril; Benazepril Sandoz; Benazeprilum [Latin]; Forteekor [veterinary]; Benazepril (INN); Benazepril Sandoz (TN); Benazepril [INN:BAN]; Forteekor [veterinary] (TN); Fortekor (TN); Lotensin (TN); CGS-14824-A; [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; [(3S)-3-({(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; [(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid

Indication

Hypertension; ICD 11: BA00-BA04; Status: Approved [1]; Malignant essential hypertension; ICD 11: BA00; Status: Approved [2]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Benazepril + Candesartan	DCJMZRD	Candesartan	Hypertension	[3]
Benazepril + Hydroxychloroquine	DCFPEZJ	Hydroxychloroquine	Alport Syndrome, X-Linked	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6374).
• [2] Amlodipine FDA Label
• [3] ClinicalTrials.gov (NCT04467931) ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
• [4] ClinicalTrials.gov (NCT04937907) Study of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)