Details of the Drug Combinations

General Information of This Drug (ID: DMHIS6Z)

Drug Name

Apilimod DMHIS6Z

Synonyms

Apilimod; STA 5326; STA-5326; GFW2K84S4L; STA5326; Apilimod [INN]; EX-A908

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Preclinical	[1]
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Therapeutic Class

Antiviral Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Apilimod + DZNep	DCCQ66I	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[2]
Apilimod + Ruxolitinib	DCFGSXH	Ruxolitinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Apilimod + Piperacetazine	DCJ9DJP	Piperacetazine	Lymphoid neoplasm (Cell Line: Mak)	[2]
Apilimod + RG6046	DC95734	RG6046	Lymphoid neoplasm (Cell Line: Mak)	[2]
Apilimod + Ruxolitinib	DCVBB7T	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Apilimod + Ruxolitinib	DCPVNYK	Ruxolitinib	Hodgkin lymphoma (Cell Line: HDLM-2)	[3]
Apilimod + Ruxolitinib	DCCBLQ4	Ruxolitinib	Hodgkin lymphoma (Cell Line: U-HO1)	[3]
Colchicine + Apilimod	DCKH9XN	Colchicine	Lymphoid neoplasm (Cell Line: Mak)	[2]
DZNep + Apilimod	DCN6AWT	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[2]
Omacetaxine mepesuccinate + Apilimod	DC1JJWZ	Omacetaxine mepesuccinate	Lymphoid neoplasm (Cell Line: Mak)	[2]
RG6046 + Apilimod	DC3NGLV	RG6046	Lymphoid neoplasm (Cell Line: Mak)	[2]
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⏷ Show the Full List of 11 DrugCom(s)

References

1	A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. April 17, 2020.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.