Details of the Drug Combinations

General Information of This Drug (ID: DMHP21E)

Drug Name

Hydromorphone DMHP21E

Synonyms

hydromorphone; Dihydromorphinone; Dimorphone; Idromorfone; Hydromorphon; Dihydromorfinon; Hydromorfona; Laudacon; DiMo; Hydromorphonum; 7,8-Dihydromorphinone; Novolaudon; Hidromorfona; Dilaudid; Dilaudid Oros; Hydromorfona [Spanish]; Dihydromorfinon [Czech]; 466-99-9; Hydromorphonum [INN-Latin]; Hidromorfona [INN-Spanish]; Palladone; 6-Deoxy-7,8-dihydro-6-oxomorphine; Morphinone, dihydro-; Idromorfone [DCIT]; Laudicon; Hydromorphone [INN:BAN]; Dilaudid-hp; 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one; DiMo; Hydromorphone HCL; Dilaudid (TN); Hydromorphone (INN); Palladone (TN); Palladone SR (TN); Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-(8CI); (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one; (-)-Hydromorphone; (5alpha)-3-hydroxy-17-methyl-4,5-epoxymorphinan-6-one; 3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one; 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone; Hydromorphone prodrug

Indication

Disease Entry	ICD 11	Status	REF
Back pain	ME84.Z	Approved	[1]
Common cold	CA00	Approved	[1]
Cough	MD12	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]
Chronic pain	MG30	Phase 3	[3]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Hydromorphone + Morphine	DCDIPAY	Morphine	Pain, Postoperative	[4]
Ibuprofen + Hydromorphone	DCMLN5A	Ibuprofen	Breast Cancer	[5]
Hydromorphone + Ropivacaine	DC1IM2N	Ropivacaine	Analgesia	[6]
Fentanyl + Hydromorphone	DCHINVQ	Fentanyl	Cancer	[7]
Hydromorphone + Acetaminophen	DC1HCDV	Acetaminophen	Acute Pain	[8]
Fentanyl + Hydromorphone	DCK1DM0	Fentanyl	Opioid Use	[9]
Hydromorphone + Acetaminophen	DC2STO7	Acetaminophen	Fusion of Spine, Lumbar Region	[10]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	Hydromorphone FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	ClinicalTrials.gov (NCT02880800) Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?
5	ClinicalTrials.gov (NCT02461056) Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
6	ClinicalTrials.gov (NCT05901441) Effect of Epidural Hydromorphone Combined With Ropivacaine in Labor Analgesia
7	ClinicalTrials.gov (NCT02084355) Study of Opioid Rotation Versus Opioid Escalation in Patients With Moderate to Severe Cancer Pain
8	ClinicalTrials.gov (NCT03553498) IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients
9	ClinicalTrials.gov (NCT03726268) Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
10	ClinicalTrials.gov (NCT03104816) The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion