Details of the Drug Combinations

General Information of This Drug (ID: DMI40NL)

Drug Name
Tolazoline   DMI40NL
Synonyms
Artonil; Benzalolin; Benzazoline; Benzidazol; Benzolin; Benzylimidazoline; Divascol; Imidalin; Imidaline; Kasimid;Lambril; Olitensol; Peripherine; Phenylmethylimidazoline; Prefaxil; Pridazole; Priscol; Priscoline; Tolazolin; Tolazolina; Tolazolinum; Vasimid; Vasodil; Vasodilatan; Dilatol ASI; Tolazine [veterinary]; Tolazoline Monohydrochloride; Ciba 3259; Benzolin (VAN); Benzolin (vasodilator); Tolazine [veterinary] (TN); Tolazolina [INN-Spanish]; Tolazoline (INN); Tolazoline [INN:BAN]; Tolazolinum [INN-Latin]; Benzolin (vasodilator) (VAN); 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-(9CI); 2-(phenylmethyl)-4,5-dihydro-1H-imidazole; 2-BENZYL-4,5-IMIDAZOLINE HCl; 2-Benzyl-2-imidazoline; 2-Benzyl-4,5-dihydro-1H-imidazole; 2-Benzyl-4,5-imidazoline; 2-Benzylimidazoline; 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole
Indication
Disease Entry ICD 11 Status REF
Cerebrovascular disease 8B2Z Approved [1]
Pulmonary hypertension BB01 Approved [2]
Vascular disease BE2Z Investigative [1]
Therapeutic Class
Vasodilator Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

85 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Tolazoline DC9360S Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acetazolamide + Tolazoline DC0KF63 Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Tolazoline DCRP1S1 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Armodafinil + Tolazoline DC3Q4LG Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Tolazoline DCQAPPG Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Tolazoline DCOT0GA Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Tolazoline DCV91KE Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cisatracurium + Tolazoline DCJIOBS Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Citalopram + Tolazoline DC8V35Q Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Tolazoline DCNRPNX Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dantrolene + Tolazoline DC864Y0 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Darunavir + Tolazoline DCDGPYE Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eflornithine + Tolazoline DC39C70 Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Entacapone + Tolazoline DCBP77D Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fenoprofen + Tolazoline DCM813Q Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydroxychloroquine + Tolazoline DCGTMG9 Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ibutilide + Tolazoline DCSW1LS Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Tolazoline DCB5CLO Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Loperamide + Tolazoline DCSQE49 Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Tolazoline DCCWT6P Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metaxalone + Tolazoline DC5KZ1D Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Tolazoline DCPEHOX Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metyrosine + Tolazoline DC9M7PA Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Tolazoline DCQECPA Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Norcisapride + Tolazoline DC4BSRG Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Olmesartan medoxomil + Tolazoline DCLVP92 Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Picoplatin + Tolazoline DC1HRDP Picoplatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Tolazoline DC9A1F5 Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Terameprocol + Tolazoline DCVH1IJ Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Ribavirin-TP DCTCPZF Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Gefitinib DC401G5 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Diethylcarbamazine DCQS8AP Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Citalopram DC99CMP Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Crotamiton DCO2Z1P Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Epinephrine DCCD1BG Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + PMID28460551-Compound-2 DC2HETX PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Tacrine DC5V6HJ Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Vinblastine DC5EGMJ Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Triapine DC5HY07 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Acitretin DCFA5M5 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Everolimus DCXIEEO Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + IT-141 DCDA5HL IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Metyrosine DCYJKR1 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Itraconazole DC5FMR2 Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Chlorzoxazone DCY8QRH Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Docetaxel DCRA42A Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + VR-776 DC3KXBV VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + WAY-100635 DCXJTCC WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Armodafinil DC6BACE Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Sulfapyridine DCBLSTJ Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Tolvaptan DCX8DHG Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + BIO-300 DCP0E8C BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + PF-02545920 DCXX62B PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Tiagabine DCTXDYK Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Diazoxide DC6JQJG Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Allopurinol DC896YR Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Idarubicin DC9HT9R Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Tolazoline + Imatinib DCCAHPP Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Ethinyl estradiol DCLQK1X Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Trimethobenzamide DCXVEZX Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Maprotiline DCOSQ8M Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Oxyphenbutazone DC8AAYQ Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Theophylline DCY0NSS Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Brincidofovir DCO7HER Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Hyodeoxycholic acid DCIOUNK Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Mycophenolic acid DCUM9LS Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Hydralazine DC48CEZ Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Mefloquine DCIUT34 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Pizotyline DCKWIDF Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Doxorubicin DCXFOXX Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Nitisinone DCWVSOB Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Sumatriptan DCT91GX Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Auranofin DC9ZU3F Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Vorinostat DC6KZT7 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Estramustine DCLPP2S Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Cerivastatin DC0D73T Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Acetohydroxamic Acid DCYT8L2 Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tolazoline + Cytarabine DCR6MM5 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Topotecan + Tolazoline DCXIDK5 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triapine + Tolazoline DCN38KU Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triflupromazine + Tolazoline DC4OK13 Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + Tolazoline DCFDRAW Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trimethobenzamide + Tolazoline DCJ3OQ2 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Valproic Acid + Tolazoline DCARNK0 Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vorinostat + Tolazoline DCB7L51 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 85 DrugCom(s)

References

1 Tolazoline FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7310).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.