Details of the Drug Combinations

General Information of This Drug (ID: DMIE1WY)

Drug Name
AG-881   DMIE1WY
Synonyms
Vorasidenib; 1644545-52-7; UNII-789Q85GA8P; 789Q85GA8P; AG881; 9UO; 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine; Vorasidenib [INN]; Vorasidenib (AG-881); SCHEMBL16393139; AG 881 [WHO-DD]; QCZAWDGAVJMPTA-RNFRBKRXSA-N; BDBM279948; EX-A2574; US10028961, Compound 101; AG 881; s8611; CS-8033; HY-104042; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoro propan-2-yl)-1,3,5-triazine-2,4-diamine; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoroprop
Indication
Disease Entry ICD 11 Status REF
Glioma 2A00.0 Phase 3 [1]
Acute myeloid leukaemia 2A60 Phase 1 [2]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abexinostat + AG-881 DC8PGIS Abexinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
AG-881 + Venglustat DC2L9IN Venglustat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
AG-881 + Idarubicin DC4XKLL Idarubicin Glioblastoma? (Cell Line: T98G) [3]
AG-881 + Rotenone DCVFR6W Rotenone Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
C646 + AG-881 DCYIX8I C646 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Gemcitabine + AG-881 DCDM9ZK Gemcitabine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 ClinicalTrials.gov (NCT04164901) Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.