Details of the Drug Combinations

General Information of This Drug (ID: DMIOUEY)

Drug Name

AMG 337 DMIOUEY

Indication

Disease Entry	ICD 11	Status	REF
Clear cell sarcoma	2A60-2C35	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AMG 337 + Panobinostat	DC76BS0	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT02016534) Phase 2 Study of AMG 337 in MET Amplified Gastric/Esophageal Adenocarcinoma or Other Solid Tumors. U.S. National Institutes of Health.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.