Details of the Drug Combinations

General Information of This Drug (ID: DMIU0VP)

Drug Name
SNX-5422   DMIU0VP
Synonyms
908115-27-5; PF-04929113; SNX-5422; SNX 5422; SNX5422; UNII-BF52J69Q8T; PF 04929113; PF-04929113 (SNX-5422); BF52J69Q8T; PF04929113; PF-4929113; cc-40; MLS006011083; SCHEMBL1220791; SCHEMBL1220790; CHEMBL1195136; SCHEMBL15604989; DTXSID50238270; C25H30F3N5O4; MolPort-023-293-502; BCPP000065; HMS3656B09; EX-A2343; BCP02427; s2656; ZINC95616595; ABP000737; ZINC100071931; ZINC252517142; AKOS027276395; SB16643; DB06070; API0008143; RL05706; SNX-5422 /; CS-0272; NCGC00346640-01; NCGC00386184-02; Glycine, trans-4-((2-(aminocarbonyl)-5-(4,5,6,7-tetrah
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Phase 1/2 [1]
Non-small-cell lung cancer 2C25.Y Phase 1/2 [1]
Chronic lymphocytic leukaemia 2A82.0 Phase 1 [1]
Neuroendocrine cancer 2B72.1 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

25 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + SNX-5422 DCVUFX1 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
Azathioprine + SNX-5422 DCJH9KS Azathioprine Hodgkin lymphoma (Cell Line: L-1236) [2]
Epothilone D + SNX-5422 DCH8XE9 Epothilone D Ewing sarcoma (Cell Line: TC-71) [2]
GDC-0084 + SNX-5422 DCQN986 GDC-0084 Hodgkin lymphoma (Cell Line: L-1236) [3]
JQ1 + SNX-5422 DC7BWUL JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
Mitomycin + SNX-5422 DC7GDHL Mitomycin Hodgkin lymphoma (Cell Line: L-1236) [3]
MK-2206 + SNX-5422 DCJRS9U MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
NVP-AUY922 + SNX-5422 DCVUQLF NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-027 + SNX-5422 DCUTGT1 OSI-027 Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + MK-1775 DCKIH13 MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Panobinostat DCRW4ZF Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
SNX-5422 + BN-2629 DC4OK7H BN-2629 Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Cantharidin DCK8TO1 Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + AT7519 DCJ498O AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Docetaxel DCSRM9I Docetaxel Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Bardoxolone methyl DCNEYZ2 Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Lestaurtinib DC9NRM1 Lestaurtinib Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Decitabine DCQT6XI Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + Ruxolitinib DCA9SRU Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
SNX-5422 + Ruxolitinib DCXGNB6 Ruxolitinib Hodgkin lymphoma (Cell Line: HDLM-2) [3]
SNX-5422 + Ruxolitinib DCBMO56 Ruxolitinib Hodgkin lymphoma (Cell Line: L-428) [3]
SNX-5422 + Fomepizole DCOLS7F Fomepizole Hodgkin lymphoma (Cell Line: L-1236) [3]
SNX-5422 + GDC-0084 DCGG28H GDC-0084 Hodgkin lymphoma (Cell Line: HDLM-2) [3]
SNX-5422 + GDC-0084 DCA9E4W GDC-0084 Hodgkin lymphoma (Cell Line: L-428) [3]
Withaferin A + SNX-5422 DCYSLOQ Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 25 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.