Details of the Drug Combinations

General Information of This Drug (ID: DMIWFRL)

• Drug Name: Tolvaptan (DMIWFRL)
• Synonyms: Samsca; OPC 41061; Benzazepine derivative, 32; OPC-41061; Samsca (TN); N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide; (-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide; 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine

Indication

Autosomal dominant polycystic kidney disease; ICD 11: GB81; Status: Approved [1]; Hyponatraemia; ICD 11: 5C72; Status: Approved [2]; Heart failure; ICD 11: BD10-BD13; Status: Phase 3 [2]; Hypernatremia; ICD 11: 5C71; Status: Investigative [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

64 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aminosalicylic acid + Tolvaptan	DCVSPRY	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Tolvaptan	DCNF32L	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Tolvaptan	DCE1XH5	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bumetanide + Tolvaptan	DC5TSB3	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Tolvaptan	DCLCDH6	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chloroquine + Tolvaptan	DC2UN2V	Chloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Tolvaptan	DCWWDI0	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clascoterone + Tolvaptan	DCR9DBO	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clopidogrel + Tolvaptan	DCD9JGA	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dactinomycin + Tolvaptan	DCW8GI8	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Dantrolene + Tolvaptan	DCB6KGF	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
FORMESTANE + Tolvaptan	DCPD827	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Tolvaptan	DCNMK0N	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Isoproterenol + Tolvaptan	DCQKK7B	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Tolvaptan	DCZL4CL	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Linagliptin + Tolvaptan	DCWJRA2	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Tolvaptan	DCY0EP2	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mebutamate + Tolvaptan	DCITR33	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mephenytoin + Tolvaptan	DCOM1E7	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Tolvaptan	DC68DQ3	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nabilone + Tolvaptan	DCWU9AM	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Tolvaptan	DC5PIKV	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oxyphenbutazone + Tolvaptan	DC8EIXR	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Tolvaptan	DCOOVOS	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ribavirin-TP + Tolvaptan	DCZ4WC8	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Spironolactone + Tolvaptan	DCQDKFK	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Tolvaptan	DCA07FS	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolazoline + Tolvaptan	DCX8DHG	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Aprepitant	DCBI9QL	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Primidone	DC1K4YQ	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Gefitinib	DCZ5CPL	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Ruxolitinib	DC2IB5K	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Tolvaptan + Kanamycin	DCDOS4K	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Terazosin	DCO2NG2	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + GYKI-52466	DC5G9NN	GYKI-52466	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Fomepizole	DC9X2Z4	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Triapine	DCU2EWP	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Everolimus	DC0I9LV	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Pepstatin	DCF10TK	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + IT-141	DCN9DON	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Palonosetron	DC6J8R5	Palonosetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Itraconazole	DCUS7NH	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Emetine	DC9ZECU	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Docetaxel	DC99HJS	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Fluspirilene	DCIT1O8	Fluspirilene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Mecamylamine	DCI7TSA	Mecamylamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Arfolitixorin	DC6O8YL	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Tiagabine	DCVLJIS	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Diazoxide	DCNNDFX	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Idarubicin	DC55D9F	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Idarubicin	DC88O48	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Tolvaptan + Brincidofovir	DCX539E	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Asenapine	DCYD4VJ	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Mycophenolic acid	DCTFVBT	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Mefloquine	DCQBLXF	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Doxorubicin	DCLSFL2	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Vorinostat	DCOPUVE	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Estramustine	DCF98B0	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Acetohydroxamic Acid	DCPZEZN	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Albendazole	DCB5QWD	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Tacrolimus	DCAL2YR	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolvaptan + Cytarabine	DCV5J3N	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triflupromazine + Tolvaptan	DCKC38Z	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Tolvaptan	DCBBVGN	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Midodrine + Tolvaptan	DCJXX75	Midodrine	Liver Cirrhosis	[5]
Tolvaptan + Furosemide	DC821OA	Furosemide	Pulmonary Arterial Hypertension	[6]

References

• [1] Tolvaptan FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2226).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT05060523) To Study Effect of the Combination of Midodrine and Tolvaptan Versus Tolvaptan Alone in Patients With Severe Hyponatremia in Cirrhosis(TOLMINA Trial)
• [6] ClinicalTrials.gov (NCT05569655) Efficacy and Safety Evaluation of Tolvaptan in the Treatment of Patients With RHF Caused by PAH