Details of the Drug Combinations

General Information of This Drug (ID: DMJ83LK)

Drug Name

A-674563 DMJ83LK

Synonyms

A 674563; A674563

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
A-674563 + Marizomib	DC7JVKO	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
A-674563 + Idarubicin	DC3IHBR	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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References

1	Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.