Details of the Drug Combinations

General Information of This Drug (ID: DMJPE61)

Drug Name

PF-02545920 DMJPE61

Synonyms

1037309-45-7; 2-((4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinoline succinate; UNII-TJ5KAZ8T5G; TJ5KAZ8T5G; PF-2545920 succinate; SCHEMBL439127; CTK8C0559; DTXSID90647726; ANW-64894; AKOS016005150; KB-80291; Quinoline, 2-((4-(1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-, butanedioate (1:1); AX8234870; TC-153639; Quinoline,2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-,succinate salt; 2-[[4-[1-Methyl-4-(4-pyridyl)pyrazol-3-yl]phenoxy]methyl]quinoline

Indication

Disease Entry	ICD 11	Status	REF
Huntington disease	8A01.10	Phase 2	[1]
Schizophrenia	6A20	Phase 2	[2]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

129 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + PF-02545920	DCVV5H5	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acarbose + PF-02545920	DCGEFLJ	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acetohydroxamic Acid + PF-02545920	DCQOATD	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aciclovir + PF-02545920	DCHF1HD	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acitretin + PF-02545920	DC68296	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Albendazole + PF-02545920	DC4SQ1R	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + PF-02545920	DC451LM	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Anamorelin + PF-02545920	DC6DV66	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + PF-02545920	DCXI9N2	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Atenolol + PF-02545920	DCI7SA1	Atenolol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Benserazide + PF-02545920	DCSFBCM	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bepridil + PF-02545920	DCPBSW7	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + PF-02545920	DC1PWJM	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Buspirone + PF-02545920	DCPDPZM	Buspirone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + PF-02545920	DCSSIK1	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cevimeline + PF-02545920	DC2Q49T	Cevimeline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorambucil + PF-02545920	DC2BBSP	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlormezanone + PF-02545920	DCW6TA7	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clascoterone + PF-02545920	DC5MJ1C	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clindamycin + PF-02545920	DCMOSYH	Clindamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Clopidogrel + PF-02545920	DCJKFPC	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Daidzin + PF-02545920	DCMVS2Q	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + PF-02545920	DCOMZ0Q	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Desoxycorticosterone pivalate + PF-02545920	DCIXRCD	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + PF-02545920	DCC01XF	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dichlorphenamide + PF-02545920	DCRMQGB	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diphenidol + PF-02545920	DCMK55P	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Efavirenz + PF-02545920	DCQKZ7T	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + PF-02545920	DCZSN3G	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + PF-02545920	DCWG702	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
FORMESTANE + PF-02545920	DCKEYIL	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Gefitinib + PF-02545920	DCGDRMN	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Guanfacine + PF-02545920	DCJ4SP5	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + PF-02545920	DCQZDAW	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
K-134 + PF-02545920	DCOVGLF	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + PF-02545920	DCXDCOV	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lefaxin + PF-02545920	DCJU5PY	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lithium Citrate + PF-02545920	DCE5B2H	Lithium Citrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + PF-02545920	DCW9YHA	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mebutamate + PF-02545920	DC8X5E5	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mecamylamine + PF-02545920	DCQCGG7	Mecamylamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + PF-02545920	DCUG7BU	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mesalazine + PF-02545920	DCUFPXE	Mesalazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metaxalone + PF-02545920	DCFPAAC	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + PF-02545920	DC1LIIC	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + PF-02545920	DCDAV65	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miglustat + PF-02545920	DC64O6S	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nitisinone + PF-02545920	DCNI90N	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + PF-02545920	DCRPQKG	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Aprepitant	DCNTHD3	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Baclofen	DCM5LBK	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Aliskiren	DCEQ96Y	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Diethylcarbamazine	DCOQ477	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Kanamycin	DCGJO36	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Dactinomycin	DC5K48O	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Epinephrine	DCPGMGG	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Trioxsalen	DCM3ADX	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Vinblastine	DCF990K	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Mephenytoin	DC2WDTZ	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Triapine	DCPP87K	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + 10-hydroxycamptothecin	DCVLW6D	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Rifampin	DCISF1C	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Pamidronate	DCHEXDD	Pamidronate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Methylergonovine	DCKYORE	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Isosorbide dinitrate	DC9OWVN	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + BHV-0223	DC7M6QM	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Chlorzoxazone	DCZAL49	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Metformin	DC76C1M	Metformin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Docetaxel	DCOCYLV	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Galantamine	DCTU1WX	Galantamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Ginsenoside Rb1	DCOXB2L	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Fibrates	DCUMKL6	Fibrates	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Armodafinil	DCS5WS4	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Naringenin	DCKCYLA	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Pentamidine	DCBDIVJ	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Arfolitixorin	DCJ3FGP	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Triflupromazine	DC3BMZX	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Trazodone	DCF2ZI5	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Isoproterenol	DCPW1O3	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Tiagabine	DCOIHWM	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Oseltamivir	DCIVP4B	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Diazoxide	DCO9HIW	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Fenoprofen	DCL0MJE	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Allopurinol	DCY28TJ	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Pargyline	DCNLFCG	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Idarubicin	DCBGFK2	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Idarubicin	DCONV0K	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
PF-02545920 + Imatinib	DC09MS2	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Probenecid	DC20FOQ	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Abacavir	DCDQZH1	Abacavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Darunavir	DC9BDF6	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Mebendazole	DCAUJ1T	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Ethinyl estradiol	DCS4KHR	Ethinyl estradiol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Olanzapine	DCGIGZ8	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Dopamine	DC62V8O	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Trimethobenzamide	DCMZ5YO	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Maprotiline	DCDBW01	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DCEXSKD	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Eptifibatide	DCS3KNM	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Leflunomide	DCWAI3G	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Novobiocin	DCSQ2FP	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Brincidofovir	DCR3PZ6	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Valproic Acid	DC99OXR	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Loperamide	DCGJDNI	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Mycophenolic acid	DC9TMKJ	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Fosfomycin	DC19H4W	Fosfomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Doxorubicin	DCW15R1	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Zileuton	DCTJ42L	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Silver sulfadiazine	DCY6KTD	Silver sulfadiazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Testolactone	DCT2GVA	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Sumatriptan	DC6Q06J	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Auranofin	DCR28OS	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + PMID28870136-Compound-43	DCUZS4K	PMID28870136-Compound-43	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + GSK2194069	DCE76DB	GSK2194069	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phenprocoumon + PF-02545920	DCJX8Q9	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + PF-02545920	DC5ROFJ	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pomalidomide + PF-02545920	DC2RZGG	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + PF-02545920	DCFWXQ9	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
SCH 727965 + PF-02545920	DCO6XF4	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tacrolimus + PF-02545920	DCA0G6B	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + PF-02545920	DCC1KHC	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terameprocol + PF-02545920	DC5EUIN	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Testosterone + PF-02545920	DCF0XJA	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Testosterone cypionate + PF-02545920	DCDOMCF	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + PF-02545920	DCNKG0V	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolazoline + PF-02545920	DCXX62B	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triamterene + PF-02545920	DCTBKUE	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triiodothyronine + PF-02545920	DC4XQS7	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ursodeoxycholic acid + PF-02545920	DC9H63S	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 129 DrugCom(s)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT01939548) An Outpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Adjunctive Treatment Of Sub-Optimally Controlled Symptoms of Schizophrenia. U.S. National Institutes of Health.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.