Details of the Drug Combinations

General Information of This Drug (ID: DMJPXZ4)

Drug Name
GSK618334   DMJPXZ4
Synonyms
Fingolimod hydrochloride; 162359-56-0; FTY720; Fingolimod HCl; Gilenya; Gilenia; Fty-720; Fty 720; Fingolimod (FTY720) HCl; Fingolimod (hydrochloride); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride; 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride; UNII-G926EC510T; Fingolimod hydrochloride [USAN]; CHEBI:63112; G926EC510T; 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride; AK-33554; 2-AMINO-2-[2-(4-OCTYL-PHENYL)-ETHYL]-PROPANE-1,3-DIOL HCL; Fingolimod-d4 Hydrochloride
Indication
Disease Entry ICD 11 Status REF
Drug abuse 6C4G.1Z Phase 1 [1]
Nasopharyngeal carcinoma 2B6B Investigative [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BMS-754807 + GSK618334 DCD8JE3 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
GDC-0980/RG7422 + GSK618334 DCXSU5Q GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
GSK618334 + PD-0325901 DC4SC6P PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
GSK618334 + THAPSIGARGIN DCQG3R2 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
GSK618334 + Mebendazole DCLG49L Mebendazole Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
GSK618334 + Mefloquine DCLZMZS Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Ym155 + GSK618334 DCPNIZO Ym155 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 7 DrugCom(s)

References

1 ClinicalTrials.gov (NCT00513279) To Investigate If Single Doses Of GSK618334 Are Safe And To Investigate Blood Levels Of GSK618334. U.S. National Institutes of Health.
2 Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.Oncotarget. 2016 Dec 6;7(49):80586-80598.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.