Details of the Drug Combinations

General Information of This Drug (ID: DMJTEMW)

Drug Name
Lubiprostone   DMJTEMW
Synonyms
Amitiza; Lubiprostone [USAN]; RU 0211; RU0211; SPI 0211; SPI0211; AMITIZA (TN); RU-0211; SPI-0211; Amitiza, RU-0211, SPI-0211, Lubiprostone; (-)-7-((2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta (b)pyran-5-yl)heptanoic acid; (-)-7-((2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta(b)pyran-5-yl)heptanoic acid; 7-((1R,4R,6R,9R)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo(4.3.0)non-9-yl)heptanoic acid; 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-yl]heptanoic acid
Indication
Disease Entry ICD 11 Status REF
Chronic idiopathic constipation DC32 Approved [1]
Therapeutic Class
Anticonstipation Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

55 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Lubiprostone DC9ICGV Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Lubiprostone DCTF8ZB Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Lubiprostone DCPVK5R Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + Lubiprostone DC0SVKA Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bosentan + Lubiprostone DC4Q46F Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Lubiprostone DCFS8ZO Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Lubiprostone DC4GNP4 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Lubiprostone DCB4G07 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Lubiprostone DCA6Y9W Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clindamycin + Lubiprostone DCPJR1G Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + Lubiprostone DCY4HGS Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ezetimibe + Lubiprostone DCKJ846 Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Baclofen DC8WGR4 Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Diethylcarbamazine DC0EHX4 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Imipramine DCF1C4T Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Epinephrine DCDFIL0 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Vinblastine DCC06SS Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Sivelestat DCQTSIT Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Anamorelin DCFSX7N Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Triapine DC75X39 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + IT-141 DCBWSKF IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Methylergonovine DCPSP9E Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Metyrosine DC8IUML Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Terameprocol DCW2S39 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Itraconazole DC3PC3O Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Carglumic acid DCD782Q Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Pazopanib DCGLYKA Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Fluspirilene DC5XWQ3 Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Niclosamide DCCN7UL Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + GINKGOLIDE A DCY19YP GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Diazoxide DCG2X7P Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Idarubicin DCBUW8R Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Lubiprostone + Imatinib DCTVZTC Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Pramipexole DCVYC8H Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Methylene blue DC6XEGW Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Maprotiline DCT60Q0 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Brincidofovir DCYHHE2 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Mycophenolic acid DCVMY0I Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Doxorubicin DCPF6N8 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Sumatriptan DCM5VQ2 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Auranofin DCXUQFX Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + PMID28870136-Compound-43 DCQR010 PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Cerivastatin DC8W1WH Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Cytarabine DCKTUKD Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Lubiprostone DCB73OG Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Moricizine + Lubiprostone DCNW7JU Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nizatidine + Lubiprostone DC1JDIO Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + Lubiprostone DCKD9S1 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ramelteon + Lubiprostone DC1UMF4 Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Theophylline + Lubiprostone DC85KNG Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Lubiprostone DCH81LP Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Lubiprostone DCH5AQJ Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triflupromazine + Lubiprostone DC2MTRJ Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Lubiprostone DCC853L Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Lubiprostone DCDQ0RM WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 55 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4242).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.