Details of the Drug Combinations

General Information of This Drug (ID: DMK0O7U)

• Drug Name: Flutamide (DMK0O7U)
• Synonyms: Apimid; ApoFlutamide; Cebatrol; Chimax; Cytamid; Drogenil; Eulexin; Eulexine; Fluken; Flulem; Flumid; FlutaGRY; Flutacell; Flutamida; Flutamidum; Flutamin; Flutandrona; Flutaplex; Flutexin; Fugerel; METHOXYCHLOR; NFBA; Niftholide; Niftolid; Niftolide; NovoFlutamide; Odyne; Oncosal; Prostacur; Prostandril; Prostica; Prostogenat; Testotard; Alphapharm Brand of Flutamide; Apo Flutamide; Apogepha Brand of Flutamide; Apotex Brand of Flutamide; Azupharma Brand of Flutamide; Cell pharm Brand of Flutamide; Chephasaar Brand of Flutamide; Chiron Brand of Flutamide; Ciclum Brand of Flutamide; Esparma Brand of Flutamide; Essex Brand of Flutamide; Fluta GRY; Fluta cell; Gry Brand of Flutamide; Hexal Brand of Flutamide; InibsaBrand of Flutamide; Ipsen Brand of Flutamide; Juta Brand of Flutamide; Kendrick Brand of Flutamide; Lemery Brand of Flutamide; Novo Flutamide; Novopharm Brand of Flutamide; PMS Flutamide; Pharmascience Brand of Flutamide; Prasfarma Brand of Flutamide; Q Pharm Brand of Flutamide; Schering Brand of Flutamide; Schering Plough Brand of Flutamide; TAD Brand of Flutamide; Tedec Meiji Brand of Flutamide; F 9397; F0663; Fluta 1A Pharma; Flutamide USP25; SCH13521; Sch 13521; Apo-Flutamide; Cebatrol, veterinary; Eulexin (TN); Fluta-GRY; Fluta-cell; Flutamida [INN-Spanish]; Flutamide(pubertal study); Flutamidum [INN-Latin]; NK-601; Novo-Flutamide; PMS-Flutamide; PUBERTAL FLUTAMIDE STUDY (PUBERTAL STUDIES OF VINCLOZOLIN; Q-Pharm Brand of Flutamide; Sch-13521; Schering-Plough Brand of Flutamide; Flutamide [USAN:BAN:INN]; Ham's F-12 medium; Eulexin, Flutamin, Drogenil,Flutamide; Flutamide (JAN/USP/INN); Alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide; M-propionotoluidide,alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro; M-Propionotoluidide, alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-(8CI); 1A Brand of Flutamide; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide; 4'-Nitro-3'-(trifluoromethyl)isobutyranilide; 4'-Nitro-3'-trifluoromethylisobutyramilide; 4'-Nitro-3'-trifluoromethylisobutyranilide; 4-Nitro-3-(trifluoromethyl)isobutyranilide; Flutamide (AR inhibitor)

Indication

Prostate cancer; ICD 11: 2C82.0; Status: Approved [1]

• Therapeutic Class: Anticancer Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Flutamide + Triptorelin	DC28TAD	Triptorelin	Prostate Cancer	[2]
Flutamide + Finasteride	DCVA5SO	Finasteride	Prostate Cancer	[3]
Goserelin + Flutamide	DC0VXSY	Goserelin	Prostate Cancer	[4]
Leuprolide + Flutamide	DCPXP5D	Leuprolide	Prostatic Neoplasms	[5]
Leuprolide + Flutamide	DCYQ0KN	Leuprolide	Prostate Cancer	[6]
Progesterone + Flutamide	DC8AEJB	Progesterone	Polycystic Ovary Syndrome	[7]
Nilutamide + Flutamide	DC4G9YW	Nilutamide	Prostate Cancer	[8]
Enzalutamide + Flutamide	DC9S8XC	Enzalutamide	Prostate Cancer	[9]
Letrozole + Flutamide	DCC2CUQ	Letrozole	Congenital Adrenal Hyperplasia (CAH)	[10]
Letrozole + Flutamide	DCYZZS0	Letrozole	Congenital Adrenal Hyperplasia (CAH)	[10]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6943).
• [2] ClinicalTrials.gov (NCT00104741) Triptorelin, Flutamide, and External-Beam Radiation Therapy or External-Beam Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer
• [3] ClinicalTrials.gov (NCT00003323) Hormone Therapy in Treating Patients With Prostate Cancer
• [4] ClinicalTrials.gov (NCT00769548) Radiation Therapy and Hormone Therapy in Treating Patients With Prostate Cancer
• [5] ClinicalTrials.gov (NCT00817739) Intermittent Hormonal Therapy With Leuprorelin and Flutamide in the Treatment of Stage D2 or TxNxM1b,c
• [6] ClinicalTrials.gov (NCT00003645) Randomized Trial of Adjuvant Hormonal Therapy in Surgically Treated Prostate Cancer Patients at High Risk for Recurrence
• [7] ClinicalTrials.gov (NCT01428193) Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
• [8] ClinicalTrials.gov (NCT00002855) Chemotherapy Plus Hormone Therapy Versus Androgen Suppression in Treating Patients With Metastatic or Unresectable Prostate Cancer
• [9] ClinicalTrials.gov (NCT02918968) Study on Enzalutamide and Flutamide in Patients With Castration Resistant Prostate Cancer
• [10] ClinicalTrials.gov (NCT00001521) Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia