Details of the Drug Combinations

General Information of This Drug (ID: DMKECZD)

Drug Name
Temozolomide   DMKECZD
Synonyms
Methazolastone; Temodal; Temodar; Temozolamide; Temozolodida; Temozolomidum; Essex brand of temozolomide; Scheringbrand of temozolomide; Temozolodida [Spanish]; Temozolomidum [Latin]; M B 39831; MB 39831; Sch 52365; M & B 39831; M&B 39831; M-39831; Sch-52365; Schering-Plough brand of temozolomide; TMZ-Bioshuttle; Temodal (TN); Temodar (TN); Temozolomide [INN:BAN]; M&B-39831; Temozolomide (JAN/USAN/INN); 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide; 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; TMZ
Indication
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [1]
Astrocytoma 2A00.0Y Approved [1]
Brain disease 8C70-8E61 Approved [1]
Central nervous system disease 8A04-8D87 Approved [1]
Cutaneous melanoma 2C30 Approved [1]
Glioblastoma 2A00 Approved [1]
Glioblastoma of brain 2A00.00 Approved [1]
Gliosarcoma N.A. Approved [1]
Grade IV astrocytoma 2A00.0 Approved [2]
Kidney neoplasm N.A. Approved [1]
Lung cancer 2C25.0 Approved [1]
Malignant glioma 2A00.0 Approved [1]
Melanoma 2C30 Approved [1]
Neuroblastoma 2D11.2 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Temozolomide + Panobinostat DCKILND Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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110 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Abexinostat + Temozolomide DC3YZN1 Abexinostat Recurrent High Grade Glioma [4]
ABT-888 + Temozolomide DC0Z3KL ABT-888 Brain and Central Nervous System Tumors [5]
ABT-888 + Temozolomide DCKKLEB ABT-888 Non-hematologic Malignancies [6]
ABT-888 + Temozolomide DCCR21I ABT-888 Functional Pancreatic Neuroendocrine Tumor [7]
Acetazolamide + Temozolomide DCVU3SE Acetazolamide Malignant Glioma of Brain [8]
Aminooxyacetic acid + Temozolomide DC86O3L Aminooxyacetic acid Unspecified Adult Solid Tumor, Protocol Specific [9]
Cabozantinib + Temozolomide DC0XXGT Cabozantinib Glioblastoma [10]
Carboplatin + Temozolomide DC3TOR7 Carboplatin Brain Tumor [11]
Carboplatin + Temozolomide DC2BSZC Carboplatin Lung Diseases [12]
Celecoxib + Temozolomide DC4NECH Celecoxib Brain and Central Nervous System Tumors [13]
Chlorpromazine + Temozolomide DCBDNPY Chlorpromazine Glioblastoma Multiforme [14]
Cilengitide + Temozolomide DCHUI3D Cilengitide Adult Giant Cell Glioblastoma [15]
Disulfiram + Temozolomide DCSQU8T Disulfiram Glioblastoma [16]
Eflornithine + Temozolomide DCUW4KF Eflornithine Glioblastoma, IDH-wildtype [17]
Enzastaurin + Temozolomide DC9LI77 Enzastaurin Glioblastoma [18]
Eribulin + Temozolomide DCN7CE3 Eribulin Refractory Solid Tumors [19]
Erlotinib + Temozolomide DCKNYM9 Erlotinib CNS Tumor, Adult [20]
Erlotinib + Temozolomide DCTAY2B Erlotinib Adult Giant Cell Glioblastoma [21]
Etoposide + Temozolomide DC0F3Y4 Etoposide Recurrent Childhood Brain Tumor [22]
Everolimus + Temozolomide DC6DA4J Everolimus Melanoma (Skin) [23]
Everolimus + Temozolomide DCELLU9 Everolimus Brain and Central Nervous System Tumors [24]
Ibudilast + Temozolomide DCZ68RQ Ibudilast Glioblastoma [25]
Isotretinoin + Temozolomide DC914WI Isotretinoin Brain and Central Nervous System Tumors [13]
Isotretinoin + Temozolomide DCU0JTG Isotretinoin Glioblastoma Multiforme [26]
Lapatinib + Temozolomide DC73YZZ Lapatinib Brain Tumors [27]
Letrozole + Temozolomide DCF09QX Letrozole Brain Tumor [28]
LY-2228820 + Temozolomide DC9H1GN LY-2228820 Adult Glioblastoma [29]
LY2835219 + Temozolomide DCNZB8A LY2835219 Relapsed Solid Tumor [30]
LY2835219 + Temozolomide DC2E1ZE LY2835219 Relapsed Solid Tumor [30]
Marizomib + Temozolomide DC2K52M Marizomib Glioblastoma [31]
Napabucasin + Temozolomide DCBQB3J Napabucasin Glioblastoma [32]
NLG8189 + Temozolomide DCS0C1F NLG8189 Glioblastoma Multiforme [33]
Olaparib + Temozolomide DC61XKW Olaparib Ewing Sarcoma [34]
Olaparib + Temozolomide DCFWYZ0 Olaparib Glioblastoma [35]
Olaparib + Temozolomide DCRHU3B Olaparib Ewing Sarcoma [34]
Pazopanib + Temozolomide DCTHJOF Pazopanib Sarcoma [36]
Plerixafor + Temozolomide DCQC820 Plerixafor Adult Ependymoblastoma [37]
Regadenoson + Temozolomide DCV4ZKH Regadenoson Blood Brain Barrier Defect [38]
Regorafenib + Temozolomide DCUREOP Regorafenib Glioblastoma, IDH-wildtype [39]
Rivoceranib + Temozolomide DC34XF9 Rivoceranib Glioblastoma [40]
Ruxolitinib + Temozolomide DCVO76S Ruxolitinib Glioma [41]
Selinexor + Temozolomide DCBIP9F Selinexor Gliosarcoma [42]
Tasisulam + Temozolomide DC1663Y Tasisulam Advanced Solid Tumors [43]
Temozolomide + Pemetrexed DC21N87 Pemetrexed Colon cancer [44]
Temozolomide + Dasatinib DC5KORW Dasatinib Brain and Central Nervous System Tumors [45]
Temozolomide + Vorinostat DC8OAFH Vorinostat Adult Glioblastoma [46]
Temozolomide + Temsirolimus DC8W5PZ Temsirolimus Adult Giant Cell Glioblastoma [47]
Temozolomide + Bortezomib DC9987E Bortezomib Brain and Central Nervous System Tumors [48]
Temozolomide + Irinotecan DC9OF7Q Irinotecan Brain and Central Nervous System Tumors [49]
Temozolomide + Vorinostat DC9PREA Vorinostat Childhood Atypical Teratoid/Rhabdoid Tumor [50]
Temozolomide + DTI-015 DC9T61Y DTI-015 Brain and Central Nervous System Tumors [51]
Temozolomide + Decitabine DCB8JG2 Decitabine Malignant Melanoma [52]
Temozolomide + Topotecan DCBFU2D Topotecan Central Nervous System Tumors [53]
Temozolomide + Afatinib DCFEBCE Afatinib Glioblastoma [54]
Temozolomide + Vandetanib DCG1SIA Vandetanib Glioblastoma Multiforme [55]
Temozolomide + Capecitabine DCHOEN1 Capecitabine Neuroendocrine Tumors [56]
Temozolomide + Lomustine DCI6LII Lomustine Brain Tumor [57]
Temozolomide + Mibefradil DCJ5YF3 Mibefradil Brain and Central Nervous System Tumors [58]
Temozolomide + Topotecan DCK4J5F Topotecan Central Nervous System (CNS) Metastases [59]
Temozolomide + Aflibercept DCKCJL0 Aflibercept Adult Anaplastic Astrocytoma [60]
Temozolomide + Valproic Acid DCLD8OY Valproic Acid High Grade Gliomas [61]
Temozolomide + Vinorelbine DCO152V Vinorelbine Metastatic Cancer [62]
Temozolomide + Pexidartinib DCP6D9U Pexidartinib Patients With Newly Diagnosed Glioblastoma [63]
Temozolomide + Imatinib DCPE0D7 Imatinib Melanoma [64]
Temozolomide + Irinotecan DCQIP3O Irinotecan Neuroblastoma [65]
Temozolomide + MK-4827 DCSFJRJ MK-4827 Recurrence of Solid Tumor [66]
Temozolomide + Lucanthone DCTCS4K Lucanthone Glioblastoma Multiforme [67]
Temozolomide + Hydroxychloroquine DCU4302 Hydroxychloroquine Brain and Central Nervous System Tumors [68]
Temozolomide + Methylprednisolone DCUFTB3 Methylprednisolone Lymphoma [69]
Temozolomide + NLG8189 DC2GZ2I NLG8189 Brain cancer [70]
Temozolomide + Azd2014 DC43VWF Azd2014 Pediatric Cancer [71]
Temozolomide + MLN8237 DC7ILW1 MLN8237 Neuroblastoma [72]
Temozolomide + LEE011 DCDQPZ4 LEE011 Neuroblastoma [73]
Temozolomide + Irinotecan DCGCGMS Irinotecan Brain Tumor, Recurrent [74]
Temozolomide + Irinotecan DCV5VC5 Irinotecan Unspecified Childhood Solid Tumor, Protocol Specific [75]
Temozolomide + MK-4827 DCVU19I MK-4827 Ewing Sarcoma [76]
Temozolomide + LEE011 DCY7510 LEE011 Pediatric Cancer [71]
Temozolomide + Ibrutinib DC0J4MX Ibrutinib Glioblastoma [77]
Temozolomide + MK-4827 DC0YERE MK-4827 Glioma, Malignant [78]
Temozolomide + Chloroquine DC6REIT Chloroquine Glioblastoma [79]
Temozolomide + Hydroxyurea DCMHPTO Hydroxyurea Glioma [80]
Temozolomide + Capecitabine DCPHQL6 Capecitabine Glioblastoma Multiforme (GBM) [81]
Temozolomide + Mycophenolate mofetil DCR0EZW Mycophenolate mofetil Recurrent Glioblastoma [82]
Temozolomide + Chloroquine DCTXR4Y Chloroquine Glioblastoma Multiforme [83]
Valaciclovir + Temozolomide DCKH3I8 Valaciclovir Malignant Glioma [84]
Valaciclovir + Temozolomide DCL6RSK Valaciclovir Glioma, Malignant [85]
Vincristine + Temozolomide DC5P04O Vincristine Brain and Central Nervous System Tumors [86]
Vincristine + Temozolomide DCU3LWE Vincristine Rhabdomyosarcoma [87]
Vismodegib + Temozolomide DCFZS7M Vismodegib Histologically Confirmed Medulloblastoma [88]
Zarnestra + Temozolomide DC8PBG7 Zarnestra Glioblastoma Multiforme [89]
Zarnestra + Temozolomide DCYW9AY Zarnestra Adult Giant Cell Glioblastoma [90]
Al3818 + Temozolomide DCGQUMB Al3818 Glioblastoma [91]
Atorvastatin + Temozolomide DCYRO34 Atorvastatin Glioblastoma Multiforme [92]
Haloperidol + Temozolomide DCLP3LM Haloperidol Glioblastoma Multiforme [93]
HKI-272 + Temozolomide DC9HUEN HKI-272 Glioblastoma [94]
LY2835219 + Temozolomide DCEQDY1 LY2835219 Neoplasms [95]
LY2835219 + Temozolomide DCNVPW7 LY2835219 Sarcoma, Ewing [96]
Methotrexate + Temozolomide DC31FMS Methotrexate Primary Central Nervous System Lymphoma [97]
Methotrexate + Temozolomide DCO4NWS Methotrexate Primary CNS Lymphoma [98]
Nabiximols + Temozolomide DCQX073 Nabiximols Glioblastoma [99]
NLG8189 + Temozolomide DCFCWYM NLG8189 Glioblastoma [100]
Octreotide + Temozolomide DC45YKA Octreotide Midgut Neuroendocrine Tumours [101]
Rivoceranib + Temozolomide DCDGNOC Rivoceranib Advanced Melanoma [102]
Sunitinib + Temozolomide DCR4EQU Sunitinib Glioblastoma Multiforme [103]
Talazoparib + Temozolomide DCSTKPV Talazoparib Ovarian Cancer [104]
Tegafur + Temozolomide DCJQBOT Tegafur Extrapancreatic Neuroendocrine Tumor [105]
Temozolomide + Lomustine DC2FA3A Lomustine Glioblastoma Multiforme [106]
Temozolomide + Valganciclovir DCTRQYQ Valganciclovir Glioblastoma Multiforme [107]
Vincristine + Temozolomide DCMOCWO Vincristine Ewing Sarcoma [108]
Temozolomide + Lomustine DCVSNPC Lomustine Anaplastic Astrocytoma [109]
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⏷ Show the Full List of 110 DrugCom(s)

References

1 Temozolomide FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7301).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT05698524) A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma
5 ClinicalTrials.gov (NCT00770471) ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
6 ClinicalTrials.gov (NCT00526617) A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients
7 ClinicalTrials.gov (NCT02831179) Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor
8 ClinicalTrials.gov (NCT03011671) Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma
9 ClinicalTrials.gov (NCT00892385) Methoxyamine and Temozolomide in Treating Patients With Advanced Solid Tumors
10 ClinicalTrials.gov (NCT00960492) Safety Study of XL184 (Cabozantinib) in Combination With Temozolomide and Radiation Therapy in the Initial Treatment of Adults With Glioblastoma
11 ClinicalTrials.gov (NCT00362817) Carboplatin and Temozolomide (Temodar) for Recurrent and Symptomatic Residual Brain Metastases
12 ClinicalTrials.gov (NCT00249964) Combination Paclitaxel, Carboplatin and Temozolomide
13 ClinicalTrials.gov (NCT00112502) Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme
14 ClinicalTrials.gov (NCT05190315) Chlorpromazine and Standard of Care in Glioblastoma
15 ClinicalTrials.gov (NCT00085254) Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
16 ClinicalTrials.gov (NCT01907165) Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide
17 ClinicalTrials.gov (NCT05879367) Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma
18 ClinicalTrials.gov (NCT00402116) Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients
19 ClinicalTrials.gov (NCT06006273) A Phase Ib Trial of Eribulin in Combination With Irinotecan and Temozolamide in Children With Relapsed or Refractory Solid Tumors
20 ClinicalTrials.gov (NCT00274833) Radiation Therapy, Temozolomide, and Erlotinib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
21 ClinicalTrials.gov (NCT00039494) Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors
22 ClinicalTrials.gov (NCT02015728) Selecting Patient-Specific Biologically Targeted Therapy for Pediatric Patients With Refractory Or Recurrent Brain Tumors
23 ClinicalTrials.gov (NCT00521001) Temozolomide and Everolimus in Treating Patients With Stage IV Melanoma That Cannot be Removed by Surgery
24 ClinicalTrials.gov (NCT00553150) Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
25 ClinicalTrials.gov (NCT03782415) Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent Glioblastoma
26 ClinicalTrials.gov (NCT00555399) Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM)
27 ClinicalTrials.gov (NCT00826241) Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma
28 ClinicalTrials.gov (NCT03122197) Study of Letrozole in Recurrent Gliomas
29 ClinicalTrials.gov (NCT02364206) Study of LY2228820 With Radiotherapy Plus Concomitant TMZ in the Treatment of Newly Diagnosed Glioblastoma
30 ClinicalTrials.gov (NCT04238819) A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma
31 ClinicalTrials.gov (NCT02903069) Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer
32 ClinicalTrials.gov (NCT02315534) A Study of BBI608 in Combination With Temozolomide in Adult Patients With Recurrent or Progressed Glioblastoma
33 ClinicalTrials.gov (NCT02052648) Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors
34 ClinicalTrials.gov (NCT01858168) Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma or Rhabdoomyosarcoma
35 ClinicalTrials.gov (NCT04614909) Study of Pamiparib in Newly Diagnosed and rGBM
36 ClinicalTrials.gov (NCT03139331) PAZIT Study for Children and Young Adults With Relapsed or Refractory Sarcoma
37 ClinicalTrials.gov (NCT01977677) Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma
38 ClinicalTrials.gov (NCT02389738) Brain Interstitium Temozolomide Concentration Pre and Post Regadenoson Administration
39 ClinicalTrials.gov (NCT06095375) Regorafenib With Temozolomide With or Without RT in MGMT-Methylated, IDH Wild-type GBM Patients
40 ClinicalTrials.gov (NCT03567135) Temozolomide Plus Anti-angiogenesis Drugs and Radiotherapy as a Treatment for Glioblastoma
41 ClinicalTrials.gov (NCT03514069) Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma
42 ClinicalTrials.gov (NCT04216329) Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma
43 ClinicalTrials.gov (NCT01284335) A Safety Study in Participants With Advanced Solid Tumors
44 ClinicalTrials.gov (NCT01985451) Pemetrexed and Temozolomide in Treating Patients With Relapsed Primary Central Nervous System Lymphoma PCNSL?Unknown status
45 ClinicalTrials.gov (NCT00869401) Dasatinib or Placebo, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
46 ClinicalTrials.gov (NCT01342757) Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma
47 ClinicalTrials.gov (NCT00316849) Temsirolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
48 ClinicalTrials.gov (NCT00512798) Bortezomib and Temozolomide in Treating Patients With Advanced Refractory Solid Tumors or Melanoma
49 ClinicalTrials.gov (NCT00099125) Radiation Therapy, Temozolomide, and Irinotecan in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
50 ClinicalTrials.gov (NCT01076530) Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors
51 ClinicalTrials.gov (NCT00004259) Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas
52 ClinicalTrials.gov (NCT00715793) Combination of Decitabine and Temozolomide in the Treatment of Patients With Metastatic Melanoma
53 ClinicalTrials.gov (NCT00109798) Temozolomide and Topotecan in Treating Patients With Primary CNS Lymphoma
54 ClinicalTrials.gov (NCT00977431) Open Label Trial to Explore Safety of Combining Afatinib (BIBW 2992) and Radiotherapy With or Without Temozolomide in Newly Diagnosed Glioblastoma Multiform
55 ClinicalTrials.gov (NCT00441142) Zactima With Temodar During Radiation Treatment for Newly Diagnosed Stage IV Brain Tumors
56 ClinicalTrials.gov (NCT00869050) Capecitabine and Temozolomide for Neuroendocrine Cancers
57 ClinicalTrials.gov (NCT00006024) Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma
58 ClinicalTrials.gov (NCT01480050) Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma
59 ClinicalTrials.gov (NCT01736800) Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid Tumors
60 ClinicalTrials.gov (NCT00650923) Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
61 ClinicalTrials.gov (NCT00302159) Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors
62 ClinicalTrials.gov (NCT00026494) Temozolomide and Vinorelbine in Treating Patients With Recurrent Brain Metastases
63 ClinicalTrials.gov (NCT01790503) A Phase 1b/2 Study of PLX3397 + Radiation Therapy + Temozolomide in Patients With Newly Diagnosed Glioblastoma
64 ClinicalTrials.gov (NCT00667953) Study of Temzolomide and Gleevec in Advanced Melanoma
65 ClinicalTrials.gov (NCT00311584) Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma
66 ClinicalTrials.gov (NCT01294735) Study of the Safety and Efficacy of MK-4827 Given With Temozolomide in Participants With Advanced Cancer (MK-4827-014 AM1)
67 ClinicalTrials.gov (NCT01587144) Safety and Efficacy Study of Lucanthone When Used in Combination With Temozolomide(TMZ) and Radiation to Treat Glioblastoma Multiforme(GBM)
68 ClinicalTrials.gov (NCT00486603) Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
69 ClinicalTrials.gov (NCT00248534) Rituximab, Temozolomide, and Methylprednisolone in Treating Patients With Recurrent Primary CNS Non-Hodgkin's Lymphoma
70 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
71 ClinicalTrials.gov (NCT02813135) European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
72 ClinicalTrials.gov (NCT01601535) Study of MLN8237 in Combination With Irinotecan and Temozolomide
73 ClinicalTrials.gov (NCT05429502) Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors
74 ClinicalTrials.gov (NCT04525014) RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors
75 ClinicalTrials.gov (NCT01141244) Temsirolimus, Irinotecan Hydrochloride, and Temozolomide in Treating Younger Patients With Relapsed or Refractory Solid Tumors
76 ClinicalTrials.gov (NCT02044120) ESP1/SARC025 Global Collaboration: A Phase I Study of a Combination of the PARP Inhibitor, Niraparib and Temozolomide and/or Irinotecan Patients With Previously Treated, Incurable Ewing Sarcoma
77 ClinicalTrials.gov (NCT03535350) Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma
78 ClinicalTrials.gov (NCT06258018) Niraparib and Temozolomide in Patients Glioblastoma
79 ClinicalTrials.gov (NCT04397679) Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma
80 ClinicalTrials.gov (NCT03463733) Hydroxy-urea and Temozolomide in Patients With a Recurrent Malignant Brain Tumor (Glioblastoma)
81 ClinicalTrials.gov (NCT03213002) Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
82 ClinicalTrials.gov (NCT04477200) Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma
83 ClinicalTrials.gov (NCT02378532) The Addition of Chloroquine to Chemoradiation for Glioblastoma
84 ClinicalTrials.gov (NCT00589875) Phase 2a Study of AdV-tk With Standard Radiation Therapy for Malignant Glioma (BrTK02). U.S. National Institutes of Health.
85 ClinicalTrials.gov (NCT03576612) GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas
86 ClinicalTrials.gov (NCT00138216) Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors
87 ClinicalTrials.gov (NCT04625907) FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
88 ClinicalTrials.gov (NCT01601184) Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway
89 ClinicalTrials.gov (NCT00050986) Phase I/II Evaluation of Temozolomide and ZARNESTRA (R115777) for Recurrent and Progressive Glioblastoma Multiforme
90 ClinicalTrials.gov (NCT00049387) Tipifarnib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
91 ClinicalTrials.gov (NCT04157478) Addition of Anlotinib Hydrochloride to the Stupp Regimen Versus the Stupp Regimen Alone for Newly Diagnosed Glioblastoma
92 ClinicalTrials.gov (NCT02029573) Efficacy and Safety of Atorvastatin in Combination With Radiotherapy and Temozolomide in Glioblastoma
93 ClinicalTrials.gov (NCT06218524) The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM
94 ClinicalTrials.gov (NCT02977780) INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
95 ClinicalTrials.gov (NCT05999994) A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
96 ClinicalTrials.gov (NCT05440786) CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma
97 ClinicalTrials.gov (NCT04514393) Ibrutinib With Methotrexate and Temozolomide for Patients With Newly Diagnosed Primary CNS Lymphoma
98 ClinicalTrials.gov (NCT02934204) Temozolomide in Treatment of Patients With Primary Central Nervous System Lymphoma
99 ClinicalTrials.gov (NCT05629702) ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
100 ClinicalTrials.gov (NCT04049669) Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
101 ClinicalTrials.gov (NCT02358356) Capecitabine ON Temozolomide Radionuclide Therapy Octreotate Lutetium-177 NeuroEndocrine Tumours Study
102 ClinicalTrials.gov (NCT03422445) A Study of Apatinib Combined With Temozolomide in Patients Witn Advanced Melanoma
103 ClinicalTrials.gov (NCT02928575) Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma
104 ClinicalTrials.gov (NCT02836028) A Study Evaluating Talazoparib in Relapsed Ovarian, Fallopian Tube, and Peritoneal Cancer
105 ClinicalTrials.gov (NCT03204032) A Study of Tegafur Combined With Temozolomide Versus Tegafur Combined With Temozolomide and Thalidomide in Subjects With Advanced Extrapancreatic Neuroendocrine Tumor
106 ClinicalTrials.gov (NCT02414165) P2/3 Randomized Study of Toca 511 & Toca FC Versus SOC in Subjects Undergoing Surgery for Recurrent GBM/AA. U.S. National Institutes of Health.
107 ClinicalTrials.gov (NCT04116411) A Clinical Trial Evaluating the Efficacy of Valganciclovir in Glioblastoma Patients
108 ClinicalTrials.gov (NCT03359005) Irinotecan and Temozolomide for Ewing Sarcoma
109 ClinicalTrials.gov (NCT00761280) Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma. U.S. National Institutes of Health.