Details of the Drug Combinations

General Information of This Drug (ID: DMKQTBA)

Drug Name

Diphenhydramine DMKQTBA

Synonyms

diphenhydramine; 58-73-1; Benadryl; Benzhydramine; Probedryl; Alledryl; Antistominum; Dihidral; 2-(Benzhydryloxy)-N,N-dimethylethanamine; Benzhydraminum; Benzhydroamina; Diphantine; Difenhydramin; Ibiodral; Difedryl; Dibondrin; Mephadryl; Desentol; Dermistina; Betramin; Benzhydril; Benzantine; Benachlor; Bagodryl; Syntedril; Novamina; Medidryl; Hyadrine; Histaxin; Etanautine; Drylistan; Diabylen; Diabenyl; Dermodrin; Benodine; Baramine; Allergical; Debendrin; Benadrin; Dabylen; Antomin; Nausen; Benapon; Dylamon; Benylin; Benylan; Benodin; Amidryl; Aleryl; Allerdryl; Allergeval; Allergina; Allergival; Antitussive; Automin; Banophen; Beldin; Belix; Bena; Benhydramin; Benzhydryl; Compoz; Dibendrin; Dibenil; Difenhidramina; Difenidramina; Dimedrol; Dimedryl; Dimehydrinate; Diphen; Diphenhist; Diphenhydraminum; Diphenylhydramin; Diphenylhydramine; Dryistan; Genahist; Hydramine; Hyrexin; Restamin; Rigidil; Siladryl; Silphen; Syntodril; Allergan B; Allermax Caplets; BENADRYL HCl; Banophen Caplets; Benadryl Allergy; Difenidramina [Italian]; Dimedrol base; Diphen Cough; Diphenhist Captabs; Diphenhydramine Base; Diphenhydramine HCl; Nytol Quickcaps; Nytol Quickgels;Twilite Caplets; Unisom Sleepgels Maximum Strength; Dormarex 2; FAR 90X2; PM 255; S51; Aller-Med; Ben-allergin; Benadryl (TN); Benadryl (hydrochloride); Beta-Dimethylaminoethanol diphenylmethyl ether; Beta-Dimethylaminoethylbenzhydrylether; Beta-dimethylaminoethyl benzhydryl ether; Difenhidramina [INN-Spanish]; Dimedrol (TN); Diphenhydraminum [INN-Latin]; Nervine Nighttime Sleep-Aid; Nytol (TN); O-Benzhydryldimethylaminoethanol; Restamin (TN); Sleep-Eze D; Sleep-Eze D Extra Strength; DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE; Diphenhydramine (JP15/INN); Diphenhydramine [INN:BAN:JAN]; Alpha-(2-Dimethylaminoethoxy)diphenylmethane; N-(Benzhydryloksy-etylo)dwumetyloamina; N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]; Beta-Dimethylamino-aethyl-benzhydryl-aether; Beta-Dimethylamino-aethyl-benzhydryl-aether [German]; N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride; N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE; N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride; 2-(Diphenylmethoxy)-N,N-dimethylethylamine; 2-(diphenylmethoxy)-N,N-dimethylethanamine; 2-Diphenylmethoxy-N,N-dimethylethylamine; 2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine; 2-benzhydryloxy-N,N-dimethylethanamine; 2-benzhydryloxyethyl-N,N-dimethylammonium; 2-diphenylmethoxy-N,N-demthylethanamine; 2PM

Indication

Disease Entry	ICD 11	Status	REF
Hyperemesis gravidarum	N.A.	Approved	[1]
Insomnia	7A00-7A0Z	Approved	[1]
Meniere disease	AB31.0	Approved	[2]
Nausea	MD90	Approved	[1]
Seasonal allergic rhinitis	CA08.01	Approved	[1]
Vasomotor/allergic rhinitis	CA08	Approved	[1]
Vomiting	MD90	Approved	[1]
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Therapeutic Class

Antiallergic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dexamethasone + Diphenhydramine	DCHSY3P	Dexamethasone	Metastatic Appendiceal Adenocarcinoma	[3]
Diphenhydramine + Ondansetron	DCB7GD0	Ondansetron	Itching	[4]
Diphenhydramine + Temsirolimus	DCG8MHZ	Temsirolimus	Prostate Cancer	[5]
Diphenhydramine + Moxifloxacin	DCRG9G1	Moxifloxacin	Cancer	[6]
Metoclopramide + Diphenhydramine	DCEHPCA	Metoclopramide	Migraine	[7]
Metoclopramide + Diphenhydramine	DCGBR5R	Metoclopramide	Nausea	[8]
Pregabalin + Diphenhydramine	DCBFZP3	Pregabalin	Lumbar Spinal Stenosis	[9]
Dexamethasone + Diphenhydramine	DCU91H9	Dexamethasone	Gastric Adenocarcinoma	[10]
Diphenhydramine + Methylprednisolone	DC8ZV0Z	Methylprednisolone	Graft Rejection	[11]
Diphenhydramine + Acetaminophen	DCKI035	Acetaminophen	Carcinoma, Non-Small-Cell Lung	[12]
Diphenhydramine + Famotidine	DCL5NQ1	Famotidine	Acute Cerebrovascular Accident	[13]
Diphenhydramine + Lactose	DCBS5VQ	Lactose	Breast Cancer	[14]
Droperidol + Diphenhydramine	DC9CI6E	Droperidol	Cannabis Hyperemesis Syndrome	[15]
Haloperidol + Diphenhydramine	DC3WH2F	Haloperidol	Migraine Headaches	[16]
Haloperidol + Diphenhydramine	DC6R690	Haloperidol	Headache, Migraine	[17]
Prochlorperazine + Diphenhydramine	DCTCT3A	Prochlorperazine	Migraine	[18]
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References

1	Diphenhydramine FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	ClinicalTrials.gov (NCT06207305) A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma
4	ClinicalTrials.gov (NCT00137202) Post Burn Pruritus Study in Patients Undergoing Wound Healing
5	ClinicalTrials.gov (NCT00887640) Impact of Temsirolimus Therapy on Circulating Tumor Cell Biology In Men With Castration Resistant Metastatic Prostate Cancer
6	ClinicalTrials.gov (NCT01017731) Study of Ramucirumab (IMC-1121B) Therapy and Corrected QT (QTc) Interval Changes
7	ClinicalTrials.gov (NCT00682734) Metoclopramide for Migraine: A Dose Finding Study
8	ClinicalTrials.gov (NCT00475306) The Montefiore Metoclopramide Study
9	ClinicalTrials.gov (NCT00638443) Lumbar Stenosis Outcomes Research (LUSTOR)
10	ClinicalTrials.gov (NCT05977998) A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology
11	ClinicalTrials.gov (NCT00771875) Randomized Trial for Mixed Acute Rejection
12	ClinicalTrials.gov (NCT04165096) KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)
13	ClinicalTrials.gov (NCT02142712) Histamine Glutamate Antagonism in Stroke
14	ClinicalTrials.gov (NCT04237090) Feasibility of a Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel
15	ClinicalTrials.gov (NCT05244460) Droperidol on Prevention of Cannabis Hyperemesis Syndrome
16	ClinicalTrials.gov (NCT02098499) Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial
17	ClinicalTrials.gov (NCT02972502) Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
18	ClinicalTrials.gov (NCT02389829) Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine