Details of the Drug Combinations

General Information of This Drug (ID: DML44FR)

Drug Name

AR-42 DML44FR

Synonyms

AR-42; 935881-37-1; OSU-HDAC42; AR 42; (S)-HDAC-42; (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide; UNII-E0GG29V0AQ; (S)-HDAC 42; E0GG29V0AQ; AR42; HDAC-42; AR-42 (HDAC-42); N-hydroxy-4-{[(2S)-3-methyl-2-phenylbutanoyl]amino}benzamide; N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide; AR-42 (OSU-HDAC42); AC1OCFYN; cc-20; OSU-HDAC 42; MLS006011089; CHEMBL191482; SCHEMBL2348844; OSU-42; DTXSID4042678; NOCAS_42678; CTK8C1969; AOB3995; N-Hydroxy-4-(3-methyl-2-(S)phenyl-butyrylamino)benzamide; MolPort-009-019-571

Indication

Disease Entry	ICD 11	Status	REF
Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[1]
Multiple myeloma	2A83	Phase 1/2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AR-42 + Ruxolitinib	DC44XMO	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
AR-42 + Marizomib	DCMAYTP	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
AR-42 + Mitomycin	DCYS4K2	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
AR-42 + Idarubicin	DCC3UGM	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
AR-42 + Ibrutinib	DCD8YVA	Ibrutinib	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
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References

1	Clinical pipeline report, company report or official report of Arno Therapeutics.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.