Details of the Drug Combinations

General Information of This Drug (ID: DML8KTN)

Drug Name

Danazol DML8KTN

Synonyms

Anatrol; Chronogyn; Cyclomen; Danatrol; Danazant; Danazole; Danazolum; Danocrine; Danogen; Danokrin; Danol; Danoval; Danzol; Ladogal; Norciden; Panacrine; Winobanin; Alphapharm Brand of Danazol; Antigen Brand of Danazol; Kendrick Brand of Danazol; Ratiopharm Brand of Danazol; Sanofi Brand of Danazol; Sanofi Synthelabo Brand ofDanazol; Sanofi Winthrop Brand of Danazol; WIN 17757; Danazol-ratiopharm; Danazolum [INN-Latin]; Danocrine (TN); WIN 17,757; WIN-17757; Win 17, 757; Danazol (JAN/USP/INN); Danazol [USAN:BAN:INN:JAN];[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol; (1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; (1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol; 1-Ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; 17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol; 17.Alpha.-Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}; 17alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol

Indication

Disease Entry	ICD 11	Status	REF
Menorrhagia	GA20.50	Approved	[1]
Breast cancer	2C60-2C65	Phase 2	[1]
Breast fibrocystic disease	N.A.	Investigative	[2]
Endometriosis	GA10	Investigative	[2]
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Therapeutic Class

Fertility Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atorvastatin + Danazol	DCVVTEI	Atorvastatin	Immune Thrombocytopenia	[3]
Ruxolitinib + Danazol	DC9WR5M	Ruxolitinib	Anemia	[4]
Baricitinib + Danazol	DC7K03A	Baricitinib	Immune Thrombocytopenia	[5]
Danazol + Teriflunomide	DCQ1YXO	Teriflunomide	Immune Thrombocytopenia	[6]
Sitagliptin + Danazol	DC64TIH	Sitagliptin	Immune Thrombocytopenia	[7]
Terbutaline + Danazol	DC62OSK	Terbutaline	Immune Thrombocytopenia	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6942).
2	Danazol FDA Label
3	ClinicalTrials.gov (NCT03460808) The Combination of Atorvastatin, Acetylcysteine and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
4	ClinicalTrials.gov (NCT01732445) Ruxolitinib Phosphate and Danazol in Treating Anemia in Patients With Myelofibrosis
5	ClinicalTrials.gov (NCT05852847) Low-dose Baricitinib Plus Danazol for Steroid-resistant/Relapse Immune Thrombocytopenia
6	ClinicalTrials.gov (NCT06176911) The Combination of Teriflunomide and Danazol for Steroid-resistant/Relapse Immune Thrombocytopenia
7	ClinicalTrials.gov (NCT05353673) The Combination of Sitagliptin and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
8	ClinicalTrials.gov (NCT04481282) The Combination of Terbutaline and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia